Endocrine Abstracts

Parathyroid hormone(PTH) is a peptide hormone that regulates ionized calcium. Primary hyperparathyroidism, in which the bone-building-destruction balance is disturbed, is due to the uncontrolled secretion of parathormone. The systemic inflammation index (SSI) is a variable that has been validated in studies aimed at evaluating the inflammation that has been frequently mentioned recently. The disruption of this bone-making destruction process affects the inflammatory process in the body. For this reason, we aimed to compare systemic inflammation index and neutrophil lymphocyte ratio in hyperparathyroidism patients before and after operation in our study.

Material and methods: In the last 5 years, 28 patients who were followed-up in the endocrinology outpatient clinic for hyperparathyroidism were included in the study. Parathormone, calcium, phosphorus, alkaline phosphatase, neutrophil, lymphocyte, and platelet values were recorded before the operation and in the 6th month of the operation. Since the normal distribution was not seen, we performed the evaluation of the results with non-parametric tests.

Results: The preoperative and postoperative alkaline phosphatase, parathormone, calcium and phosphorus values of the patients were found to be significantly different. However, although their mean values differed (Table 1), the systemic inflammation index and neutrophil-lymphocyte ratio did not differ significantly. (Table 2)

Discussion: Systemic inflammation index and neutrophil lymphocyte ratio are remarkable markers in recent years. In our study, the mean of preoperative and postoperative SSI was found to be 683 and 494, respectively. Mean and median values show a postoperative decrease as we expected. However, no statistical difference was found. Insufficient number of patients can cause statistical significance. Reducing the type 2 error by expanding the number of samples will show the result of this situation.