Endocrine Abstracts

Introduction: Due to the association of hyperuricemia with conventional cardiovascular risk factors, it is difficult to determine whether uric acid is an independent risk factor for the development of renal failure. The objective of this study was to investigate the correlation between uric acid levels and kidney function in type 2 diabetics.

Methods: This was a descriptive cross–sectional study carried out from March to September 2017 on 122 diabetic patients hospitalized at the National Institute of Nutrition. Each patient underwent a clinical examination with a standard assessment including the determination of creatinine and uric acid. Creatinine clearance was calculated using the CKD–EPI formula.

Results: The average age of our patients was 52.4 ± 7.3 years. The sex ratio was 0.96. All patients in our population were type 2 diabetics and the average duration of diabetes was 11.07 ± 3.3 years of which 78.7% were on insulin therapy. The patients in our study were smoking at 35.2%, sedentary at 39.8%, hypertensive at 45.1% and presented with biology a hyper-LDLemia at 56.2%. Uricemia was positively correlated with creatinine level (P = 0.41; P < 0.05) and inversely correlated with creatinine clearance. The level of uric acid varied according to the stage of the renal insufficiency; indeed it increased if the renal function was deteriorated (P < 0.005). Uricemia is also positively and statistically correlated with the number of cardiovascular risk factors in type 2 diabetics (P < 0.05).

Conclusion: Our work has shown that uric acid levels are correlated with kidney function which could be an aggravating factor for this impairment. However, our population was small and not representative of the population, hence the need for large–scale studies.