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Endocrine Abstracts (2020) 70 EP170 | DOI: 10.1530/endoabs.70.EP170

1Centre Assistencial Universitary León, Endocrinology and Nutrition, León, Spain; 2Centre Assistencial Universitary León, Digestive Service, León, Spain


Background: NAFLD(non–alcoholic fatty liver disease) includes; non–alcoholic fatty liver(NAFL), non–alcoholic steatohepatitis (NASH) and its complications (fibrosis, cirrhosis and hepatocellular carcinoma). These diseases are currently the most common cause of liver disease in western countries, due to the obesity and DM2 epidemic. There are scores that determine the risk of liver fibrosis in a non–invasive way.

Aims: To determine the prevalence of liver fibrosis diagnosed by FIB4 score, NAFLD fibrosis score and Hepamet fibrosis score in patients with morbid obesity. To evaluate differences in the risk of fibrosis in patients with morbid obesity with or without DM2.

Methods: Cross–sectional observational study of a sample of 95 high–risk obesity patients. Anthropometric variables (weight, size and BMI), analytical variables (glucose, insulin, AST, ALT, albumin and platelets) and non–invasive markers of liver fibrosis (FIB4, NAFLD, Hepamet) were collected. The risk of fibrosis was compared with the presence or absence of DM2.

Results: 95 patients; 73.7% are women and 24.2% had DM2. Mean age 44.22 (DE 8.34) years, weight 122.4 (RIC 84) Kg, BMI 45.82 (DE5.22) kg/m2. 94.7% of patients have FIB4 <1.30 (without fibrosis or mild fibrosis); 3.2% FIB4 1.30–2.67 (undetermined) and 2.1% FIB4 > 2.67 (advanced fibrosis). 28.4% of patients have NAFLD <–1.45 (without fibrosis or mild fibrosis), 65.3% NAFLD –1.45–0.675 (grey area) and 6.3% NAFLD > 0.675 (advanced fibrosis). 85.1% of patients have Hepamet <0.12 (without fibrosis or mild fibrosis), 9.6% Hepamet 0.12–0.24 (Grey area) and 5.3% Hepamet >0.24 (advanced fibrosis). The risk scores for fibrosis in patients with obesity and DM2 are reflected in Table 1.

Table 1
SCORESDiabetesNo diabetesP
NAFLDWithout fibrosis or mild fibrosis4, 3 %36, 1 %<< 0, 001
Grey area78, 3 %61, 1 %
Advanced fibrosis17, 4 %2, 8 %
Total100 %100 %
FIB4Without fibrosis or mild fibrosis95, 7 %94, 4 %0, 34
Undetermined4, 3 %2, 8 %
Advanced fibrosis0 %2, 8 %
Total100 %100 %
HepametNo fibrosis o leve45, 5 %97, 2 %< 0, 001
Grey area36, 4 %1, 4 %
Advanced fibrosis18, 2 %1, 4 %
Total100 %100 %

Conclusions: There is a high prevalence of liver fibrosis in patients with morbid obesity. Patients with obesity and DM2 have a higher risk of fibrosis estimated with NAFLD and Hepamet fibrosis score. In patients with obesity, DM2, or other risk factors, the risk of liver fibrosis should be evaluated as it may condition the long–term prognosis.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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