Endocrine Abstracts

Background: The frequency of prediabetes is increasing as the prevalence of obesity rises worldwide. Hyperglycemia, insulin resistance, inflammation and metabolic derangements associated with concomitant obesity cause endothelial dysfunction in prediabetics, leading to increased risk of cardiovascular and renal disease.

Objective: To get a general perspective on the complex relationship between cardiovascular diseases onset, and pre–diabetes

Methodology: 100 obese patients compared to 45 normal controls The study was conducted between June 2018 and april 2018 .All subjects were submitted to history taking, clinical examination including wasit circumference, BMI, Hb A1c, Fasting blood glucose, lipid profile, carotid artery duplex and Brachial artery flow media dilation (FMD)

Results: Mean age of our patients was 30 ± 0.3 years, BMI :30.26 ± 3.08, cholesterol: 240 ± 22.1 mg/dl, triglycerides : 105 ± 12.2 mg/dl, LDL :140.7 ± 32.1 mg/dl, HDL : 38.45 ± 9.5 mg/dl, and A1C : 5.95 ± 0.2. There was statistically significant difference in Carotid intimal media thickness between prediabetic and controls (0.10 ± 0.02/0.08 ± 0.01) (P ± 0.01). However, there was no statistical significance difference between patient and control regarding FMD: (13.40 ± 12.59 /8.63 ± 1.01) (P = 0.26).

Conclusion: Screening for prediabetes and early management is of utmost importance for prevention of cardiovascular morbidity as it is an incipient for premature atherosclerosis, endothelial dysfunction follow changes in CIMT, which highlights that screening of CVS in prediabetics should be done by CIMT and not by FMD.