Endocrine Abstracts

Aims: The aim of our study is to assess the efficacy of lifestyle modification and picolinate chromium intake in preventing diabetes mellitus type 2 (DM 2)

Materials and methods: The study included 100 patients (69 m 258 f) 25–65 years with impaired glucose tolerance (IGT) and newly diagnosed DM 2. Patients were divided into 2 groups matched by age, weight, body mass index (BMI), waist-to-hip ratio (WHR). Research group included 54 patients who carried out recommendations of a balanced diet, physical activity and picolinate chromium was taken 200 mkg per day for 1 month. Control group included 46 patients who did not lifestyle modification. The study was 24 weeks. We measured fasting plasma glycated hemoglobin (HbA1c,%) and related to fasting leptin (FL).

Results: Patients of the research group demonstrated reduction of BMI (–3.2 ± 2.1 kg/m²) and WHR (–0.02 ± 0.025) (P < 0.01 for all) and positive dynamics of HbA1c (P < 0.001). Persons of the control group had increase BMI, WHR as also HbA1c elevation (P < 0.05). The main novel finding was that median serum leptin in research group decreased on –23.9% (P < 0.01) and increased in control group on +27.6% (P < 0.01). Among subjects with IGT from the research group, HbA1c normalized in 49.3% (P < 0.001) and serum leptin levels decreased on 26.9% (P < 0.01). In control group HbA1c normalized in 4.5% (P < 0.01). Among patients of the research group was a reduction of DM 2 by 11.9% and an increase in the control group by 35.1%.

Conclusion: Lifestyle modifications with picolinate chromium intake leads to the restoration of glucose homeostasis and preventing DM 2.