ECE2020 ePoster Presentations Thyroid (122 abstracts)
Epidemiological aspects of medullary thyroid cancer as a component of multiple endocrine neoplasia type 2 in the Republic of Belarus
Yuliya Dydyshka 1 , Alla Shepelkevich 1 , Victor Kondratovich 2 , Tatiana Leonova 2 , Anna Portyanko 3 , Alena Subach 3 , Alexandra Sosedkova 2 , Alena Yurenia 4 , Tatsiana Chakhovich 3 & Sergey Smirnov 3
1Belarusian State Medical University, Endocrinology Department, Belarus; 2Public Health Institution Minsk City Clinical Oncologic Dispensary, Belarus; 3N.N. Alexandrov National Cancer Centre of Belarus, National Molecular Genetics Centre of Cancer Research, Belarus; 4Minsk Endocrinology Medical Center, Belarus
Multiple endocrine neoplasia type 2 (MEN2) is a hereditary condition with an autosomal dominant type of inheritance. It is evident that MEN2 is characterized by the presence of Medullary Thyroid Cancer (MTC) as a permanent symptom, the combination of which with pheochromocytoma and parathyroid syndrome is referred to as MEN-2A syndrome. The aim of our study was the creation of a database of patients with MTC and analysis of the data.
Materials and methods: The study is carried out in the framework of the State Program ‘Oncological diseases’ on the task ‘To develop and implement effective technologies for the diagnostic detection and observation of patients with multiple endocrine neoplasia type 2A’. The selection of participants for inclusion was carried out from the Cancer Register of the Republic of Belarus and the medical documentation of the Republican Center for Thyroid Tumors. Patient’ data from 1987 to 12/31/2019 were included.
Results: A database of patients with MTC has been compiled containing information on 591 patients, of which 183 patients died. Currently included 420 (71.1%) women and 171 (28.9%) men. The average age at the moment of diagnosis was 53.1 (43.2–61.8) years; 53.2 (43.7–62.6) years for women and 52.5 (41.6–59.4) for men (U = 32944, P = 0.115). Significant differences in age weren’t found among men and women. 76.1% patients (450 people) lived in the city and 23.9% – (141 people) in the countryside. The second tumor was discovered in 7.8% patients (46 people). Based on gender, 8.8% (37 people) of women and 5.3% (9 people) of men had the second tumor (χ2 = 2.13, P = 0.145). A concomitant endocrine tumor was present in 1.7% patients (10 people); 1.4% of women (6 people) and 2.35% of men (4 people) (F = 0.61 P = 0.433). Retrospective died patient’ data analysis (183 patients). Life expectancy after diagnosis was 4.5 (1.4–9.5) years. In a woman (108 people) 4.9 (1.2–10.2) years and in men (75 people) 4.1 (1.5–7.8) years no significant differences were found (U = 3746.5 P = 0.389). 18.6% patients (34 people) died within 1 year, 19.7% patients (35 people) lived for more than 10 years. Five-year survival rate is 44.6% (79 patients).
Conclusions: Medullary thyroid cancer is more common in women, the average life expectancy after diagnosis is 4.5 years. A concomitant tumor in 7.8% of patients requires genetic verification of the MEN.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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