ECE2020 ePoster Presentations Thyroid (122 abstracts)
Magnitude of increase in levothyroxine requirements during pregnancy in women with pregestational hypothyroidism in navarra (Spain)
Patricia Munarriz Alcuaz , Nerea Eguilaz Esparza , Ander Ernaga , Maria Dolores Ollero Garcia-Aulló , Emma Anda Apiñariz , Ana Iriarte Beroiz , Ana Irigaray Echarri & Amaya Sainz De Los Terreros Errea
Complejo Hospitalario de Navarra, Spain
Introduction: Hypothyroidism during pregnancy has been asociated with adverse maternal and neonatal outcomes. During pregnancy, maternal levothyroxine (LT4) dose requirements increase. The aim of this study is to determine the increase of LT4 doses during pregnancy in pregestational hypothyroid women.
Methods: We included 76 hypothyroid pregnant women. We analyzed analytical and clinical characteristics of these patients, as well as the increase of LT4 requirement during pregnancy. We used the statistical software SPSS version 20.
Results: Fifty-two women had autoimmune hypothyroidism (68.4%). The mean prepregnancy TSH was 2.46 ± 1.25 mU/l and the prepregnancy LT4 requeriment was 75.3 ± 32.3 µg/d. An increase in the LT4 dose was necessary in 64 women (84.2%). The mean LT4 requirement increased 44 ± 45 percent. Women with LT4 ≤ 50 µg/d increased LT4 by 63%, those between 51–100 µg/d and > 100 µg/d increased by 33% and 25% respectively (P = 0.008). Women with higher levels of anti-Tg antibodies required a higher LT4 dose (70% vs. 37%, P = 0.025). There is also a higher dose increase in women with prepregnancy TSH > 2.5 mU/l, but these differences were not statistically significant.
Conclusion: Most pregestational hypothyroid women require an increase in daily substitutive doses of LT4 during pregnancy. The mean LT4 requirement increased 45% percent during pregnancy. Women with lower prepregnancy LT4 requirement and women with higher levels of anti-Tg antibodies needed a higher dose increase.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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