Endocrine Abstracts

The aim of the study was to study the incidence of osteo-articular complications in patients with acromegaly in the Ferghana Valley.

Materials and methods: 129 patients with acromegaly in the Ferghana Valley who were included in the national register of acromegaly were examined. Of these, men – 46 (35.7%), women – 83 (64.3%). The average age of the patients was (48 ± 8.7 years). By age, patients were divided into three groups: 1 group – up to 30 years, 2 gr. –30–44 years, 3 gr. – 45 years and older. The diagnosis of acromegaly was established on the basis of the clinical manifestations of the disease and was confirmed by high serum levels of GH, IGF-1 levels

Results: According to the national register of patients with acromegaly, 2019(Republic of Uzbekistan), the incidence of osteoarticular neuromuscular complications was 82.9%, osteoarticular neuromuscular complications were most common among patients with acromegaly – arthropathy (57.4%), followed by carpal tunnel syndrome (49, 6%) and osteoporosis (48.9%). At the time of diagnosis, in most cases (more than 2/3 of cases) macroadenomas are detected, which may be associated with a delayed diagnosis and imposes difficulties in surgical treatment of these tumors. As the results showed, the examined patients had a high frequency of macroadenomas, with their prevalence in the Andijan (47.5%, P < 0.05) region. In general, macroadenomas and giant pituitary adenomas are more often identified in patients of Ferghana Valley.

Conclusion: In the Ferghana Valley, acromegaly prevails among women, while acromegaly is common over the age of 45 (P < 0.05) years in all regions of the Ferghana Valley. The highest frequency of MSC was identified in the Ferghana region, followed by the Namangan region and the frequency of MSC in Andijan region is relatively lower. Macroadenomas were more often present in patients with acromegaly of the Ferghana Valley, with their prevalence in Andijan region.

Keywords: acromegaly, musculoskeletal complications, arthropathy, osteoporosis