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Endocrine Abstracts (2020) 70 EP551 | DOI: 10.1530/endoabs.70.EP551

ECE2020 ePoster Presentations Hot topics (including COVID-19) (57 abstracts)

Metabolic profile of a diabetic population on statins

Eya Safi 1 , Yosra Htira 2 & Faika Ben Mami 2

1National Nutrition Institute, Tunisia; 2National Nutrition Institute, C, Tunisia

Dyslipidemia is a frequent pathology, especially in diabetics, which may require the use of lipid-lowering drugs such as statins. Our goal is to determine the impact of these molecules on the metabolic profile of a diabetic population with dyslipidemia.

Methods: This is a retrospective study including 150 patients followed at the Tunis nutrition institute for diabetes and dyslipidemia.

Results: The average BMI was 31.4 ± 6.1 kg/m2. Waist circumference was high especially among women. Over three-quarters (76%) of the patients were hypertensive. Average fasting glucose was 13.12 mmol/l with extremes ranging from 5.3 to 24.9 mmol/l. The average HbA1c level was 9.62 ± 2.16%. The mean duration of statin therapy was 2.2 ± 2.6 years. After being put on statins, the average BMI and waist circumference both increased significantly (P = 0.007 and P = 0.029 respectively). Both systolic and diastolic blood pressure increased but not significantly. Fasting blood sugar became significantly higher (P = 0.039). The average HbA1c decreased but this decrease was not significant. Regarding lipid parameters, total cholesterol decreased by 1.02 ± 1.25 mmol/l (P < 0.001). Triglyceridemia decreased but not significantly (P = 0.15). HDL cholesterolemia decreased by 0.035 ± 0.27 mmol/l without this being significant. The uricemia also decreased under statins but not significantly.

Conclusion: Statins have modified the metabolic profile of our population, especially anthropometric and biological parameters, which underlines the importance of clinical and biological monitoring after taking these molecules.

Volume 70

22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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