Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Oral Communications

Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition

ea0073oc12.1 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Prevention of glucocorticoid-induced adipose dysfunction through selective activation of β3-adrenergic signaling in mice

Gado Manuel , Heinrich Annett , Wiedersich Denise , Noll Monique , Bornstein Stefan R. , Rauner Martina , Hofbauer Lorenz C. , Henneicke Holger

Despite their therapeutic effectiveness, glucocorticoids’ (GC) clinical usage is frequently limited due to the deleterious metabolic effects. GC-induced obesity arises from excessive fat accumulation in white adipose tissue (WAT) as well as suppressed thermogenic capacity in brown adipose tissue (BAT). Since the sympathetic nervous system (SNS) plays a fundamental role in adipose tissue biology, we examined the interaction between GCs and SNS signaling in the adipose orga...

ea0073oc12.2 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Improved glucose metabolism and decreased weight gain in leptin-resistant, IGFBP2-deficient, db/db mice induced by AZP-3404, a 9-amino acid analog of IGFBP2

Culler Michael D. , Milano Stéphane , Ovize Michel , Delale Thomas , van der Lelij Aart Jan , Clemmons David

Insulin-like growth factor binding protein-2 (IGFBP2) has been demonstrated to be a key mediator of the peripheral actions of leptin, and its deficiency is associated with impaired metabolic function. The metabolic activity of IGFBP2 can be localized to a unique heparin-binding domain (HBD-1) within its structure. AZP-3404 is a 9-amino acid analog of the IGFBP2 HBD-1 that has been demonstrated to increase glucose uptake by differentiated mouse myotubes in vitro, and to increas...

ea0073oc12.3 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Comparative evaluation of empagliflozin, canagliflozin and sitagliptin cardioprotective effect in diabetic rats with experimental myocardial infarction

Simanenkova Anna , Minasian Sarkis , Karonova Tatiana , Vlasov Timur , Timkina Natalya , Khalzova Aleksandra , Shpilevaya Oksana , Shimshilashvili Anzhelika , Timofeeva Valeria , Borshchev Yury , Galagudza Mikhail

Background:Myocardial infarction (MI) is one of the leading causes of mortality in patients with type 2 diabetes mellitus (DM), therefore it is essential to give preference to a glucose-lowering drug having most prominent cardioprotective properties. Sodium-glucose co-transporter-2 inhibitors (SGLT-2i) have demonstrated an ability to decrease heart failure manifestations, cardiovascular death frequency not having a certain influence on MI occurrence. On ...

ea0073oc12.4 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Improvements in long-term appetite-regulating hormones in response to a combined lifestyle intervention for obesity

Kuckuck Susanne , van der Valk Eline S. , Scheurink Anton J. W. , van den Berg Sjoerd A. A. , van Rossum Elisabeth F. C.

IntroductionAltered levels of hormonal appetite regulators have been observed in obesity (BMI ≥ 30.0 kg/m2), most prominently increases of insulin and leptin (indicating resistance) as well as decreases of adiponectin–all of which are long-term energy regulators and adiposity signals. Disrupted signaling of these hormones may have detrimental effects on metabolism, but may also promote weight gain. Weight loss is often accompanied ...

ea0073oc12.5 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effects of the ghrelin gene-derived peptides on adipose browning and thermogenesis

Congiusta Noemi , Gesmundo Iacopo , Pagliaro Pasquale , Ghigo Ezio , Penna Claudia , Granata Riccarda

White adipose tissue (WAT) stores excess energy as triglycerides, while brown adipose tissue (BAT) dissipates energy through heat, acting as a defence against cold and obesity and as a positive regulator of metabolic functions. BAT thermogenic functions are mainly induced by mitochondrial uncoupling protein-1 (UCP-1), which induces uptake of lipids and glucose to sustain oxidation and thermogenesis in both brown and beige adipocytes. The ghrelin gene-derived peptides, acylated...

ea0073oc12.6 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Molecular and functional mapping of POMC neuronal heterogeneity in obesity

Léon Stéphane , Simon Vincent , Clark Samantha , Dupuy Nathalie , Cota Daniela , Quarta Carmelo

The brain is critically involved in the regulation of energy balance and glucose homeostasis. Depending on the levels of energy available in our body, the activity of a group of hypothalamic neurons expressing the neuropeptidergic marker proopiomelanocortin (POMC) changes and it plays a key role in maintaining energy balance. When POMC neuronal activity is altered, this can lead to impaired energy homeostasis and therefore to obesity. However, POMC neurons are highly diverse, ...