Endocrine Abstracts

IntroductionTP53 mutations have been rarely reported in pituitary tumours. Recently two exploratory exome sequencing studies have identified somatic TP53 mutations in a small number of functional corticotroph tumours (6/18 and 4/10) with USP8 wild type (wt) status, suggesting that they may be more frequent than previously thought. Nevertheless, the clinical impact of those mutations is still unknown.AimTo det...

We determined in vitro activity of 17β-estradiol and or progesterone on glutamate conversion to GABA in different GABAergic regions from the brain of castrated and non-castrated rats. The glutamate decarboxylase catalyzes this conversion; there are two different isotypes of glutamate decarboxylase, GAD65 and GAD67. Whereas GAD65 is a membrane enzyme, GAD67 is present in the supernatant obtained after centrifuging to 14,...

IntroductionEvidence suggests that adults with growth hormone deficiency (AGHD) exhibit metabolic abnormalities that are typical of the metabolic syndrome and are risk factors for type 2 diabetes (T2D). Concerns about undesirable effects of growth hormone replacement therapy (GHRT) on glucose metabolism have been raised, but the risk of T2D from AGHD has mixed evidence. This analysis aims to evaluate cardiovascular (CV) and metabolic safety of GHRT in th...

Neurogenesis, a process by which new neurons are generated from precursors, still persists in discrete regions of the adult hippocampus. The hippocampus is critical for learning and memory and is a main target of AD, which causes massive neuronal death, reduction in neurogenesis and impairment in cognitive functions. Therefore, preventing neuronal loss or increasing the production of new neurons may represent a potential therapeutic strategy to reduce AD-induced cognitive decl...

Somatostatin (SST), Cortistatin (CORT), Neuronostatin (NST) and their receptors [SST/CORT-receptors (sst1–5/sst5TMD4-TMD5) and NST-receptor (GPR107)] comprise a hormonal pleiotropic system involved in the regulation of multiple pathophysiological functions. Certain components of this system are dysregulated in endocrine-related cancers, including prostate cancer (PCa), wherein we have found that alterations in specific components of this regulatory system [i.e. NST-GPR10...

BackgroundMPOWERED, a large phase 3 trial, assessed maintenance of response to oral octreotide capsules (OOC; MYCAPSSA) compared to injectable somatostatin receptor ligands (iSRLs) in patients with acromegaly who responded to OOC and iSRLs (octreotide or lanreotide). OOC were recently approved in the US for patients with acromegaly who responded to and tolerated iSRLs.MethodsEligibility criteria included age ...