Endocrine Abstracts

Pheochromocytomas are catecholamine-producing tumours with diverse cardiovascular and metabolic outcomes including insulin resistance and weight loss. However, impacts on adjacent and distal fat depots are not fully defined and more particularly concerning induction of beige/brown adipose tissue (AT). The aim of the study is to characterize the cellular composition, the metabolic function and the expression of brown AT markers in matched perirenal (PRAT) and abdominal subcutan...

The combination of hypertension and type 2 diabetes mellitus (T2DM) greatly increases the risk of adverse cardiovascular events. Identification of factors which accelerate the development of atherosclerosis, it is important to more fully understand the mechanisms of progression of these diseases.The aim is to study the relationship between levels of transforming growth factor-β1 (TGF-β1), insulin-like growth factor-1 (IGF-1) and lipid peroxidat...

BackgroundSerum urate (SU) has been positively and independently associated with type 2 diabetes in observational studies, but causal roles remain unclear.1 Triglycerides and glucose (TyG) index can be a useful and easily performed indicator of insulin resistance for daily clinical practice.2 The aim of this study was to evaluate the association between SU and TyG index in 22-year-old participants of a birth cohort.<p class="abs...

Sex hormone-binding globulin levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production. The main objective of this study was to assess if the adult associations between TNFα, Adiponectin and SHBG...

ObjectiveTo determine predictive factors of co-existing autoimmunity in children with type 1 diabetes mellitus (T1D).Material and methods64 children with combined autoimmune pathology (T1D and autoimmune thyroid diseases or celiac disease) - main group, age 12.14±3.54 years) and 81 patients with only T1D (comparison group, age 11.57±3.34 years) were recruited. Groups were comparable in age (P</e...

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with Cushing’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

IntroductionEpidemiological studies have suggested that obesity during childhood increases the risk of developing metabolic comorbidities, such as type 2 diabetes, later in life. Childhood obesity is a complex disease whose molecular mechanisms are not completely elucidated. However, studies have demonstrated that approximately 65% of the variation associated with obesity is due to genetic factors. In this context, a system biology approach could contrib...

IntroductionDiabetes, a metabolic disorder characterized by abnormal blood glucose levels, is a serious chronic disease that implies an important public health problem. Being Insulin the main hormone for modulating blood glucose levels, subcutaneous injections are the main way for its administration in the diabetes treatment. However, this way of administration can lead to poor patient compliance, apart from several side-effects. Although other ways of a...