Endocrine Abstracts

Fascin-1(FSCN1) is an actin-bundling protein expressed in several solid carcinomas and often associated to an invasive and aggressive phenotype as it is involved in cytoskeleton rearrangement and filopodia formation. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy characterized by a poor prognosis, particularly when metastatic at diagnosis. Complete surgical resection of the tumor mass is the main therapy for ACC patients in addition to the adjuvant administratio...

The adrenal gland displays an important role in integrating neuronal, immune, vascular, metabolic and endocrine signals under a common organ capsule. The adrenal is the central organ of the stress response system, responsible for responses to acute and chronic stress stimuli and, thereby, playing a major role in numerous stress-related disorders. While for other diseases translational scientists developed programs to generate healthy cells to regenerate damaged tissues in pati...

The adipose tissue (AT) is an important endocrine organ. Upon energy imbalance, the adipose cells become dysfunctional, supporting the development of metabolic pathologies and tumours. The adipose cell is among the main actor of the tumor microenvironment, and is able to establish a crosstalk with the cancer cell resulting in a reciprocal reprogramming. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy affecting the adrenal cortex. In the most aggressive forms, can...

Computerized tomography (CT) texture analysis (TA) provides a valuable amount of quantitative data on single voxels and their relationship in a target lesions, giving additional value to the CT scan. CTTA has been applied to several oncologic diseases. We aimed to correlate the data derived from CTTA of pheochromocytoma to clinical, biochemical and histopathological data in 30 consecutive patients. Pheochromocytoma was confirmed at histology. The CTTA was performed on unenhanc...

IntroductionPheochromocytoma might be associated with hypercortisolism and post-operative adrenal insufficiency. The aim of this study is to determine the frequency of cortisol dysregulation before and after pheochromocytoma surgery.MethodsSingle center retrospective study of consecutive pheochromocytoma patients investigated in the Endocrinology department of Cochin Hospital before and after surgery from 200...

BackgroundBenign adrenocortical tumours are found in 3–5% of adults and can be non-functioning (NFAT) or associated with cortisol excess. The latter group divides into patients with clinically overt signs (adrenal Cushing’s syndrome, CS) and patients lacking CS signs (mild autonomous cortisol excess, MACE). The 1 mg-overnight dexamethasone suppression test (DST) further differentiates MACE into MACE-1 (possible MACE; post-DST cortisol 50–1...

BackgroundIncreased mortality risk of patients with adrenal insufficiency has been inconsistently reported. This might have resulted from the disparity of time and place of clinical care between the study patients and reference population. Also, data of patients with secondary adrenal insufficiency was limited as majority focused on other types of pituitary disorders. Therefore, we compared all-cause mortality of patients with primary and secondary adren...

BackgroundThe aim of the study was to evaluate urine steroid metabolomics by gas chromatography–mass spectrometry (GC–MS) for the adrenocortical carcinoma (ACC) metastases` biomarkers detection in patients after the surgery.Patients and methods33 postoperative ACC patients were examined before and after the surgery. The median age was 47 years (41–60). The Weiss score was more than 3 points acc...