Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Presented Eposters

Presented ePosters 11: Adrenal and Cardiovascular Endocrinology

ea0073pep11.1 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Fascin-1, a novel-circulating marker for the prognosis of the metastatic adrenocortical carcinoma

Cantini Giulia , Canu Letizia , De Filpo Giuseppina , Ercolino Tonino , Fei Laura , Nesi Gabriella , Maggi Mario , Mannelli Massimo , Luconi Michaela

Fascin-1(FSCN1) is an actin-bundling protein expressed in several solid carcinomas and often associated to an invasive and aggressive phenotype as it is involved in cytoskeleton rearrangement and filopodia formation. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy characterized by a poor prognosis, particularly when metastatic at diagnosis. Complete surgical resection of the tumor mass is the main therapy for ACC patients in addition to the adjuvant administratio...

ea0073pep11.2 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Establishment of novel multidimensional models for the adrenal gland and adrenal tumors

Shapiro Igor , Peitzsch Mirko , Steenblock Charlotte , Bornstein Stefan , Constanze Hantel

The adrenal gland displays an important role in integrating neuronal, immune, vascular, metabolic and endocrine signals under a common organ capsule. The adrenal is the central organ of the stress response system, responsible for responses to acute and chronic stress stimuli and, thereby, playing a major role in numerous stress-related disorders. While for other diseases translational scientists developed programs to generate healthy cells to regenerate damaged tissues in pati...

ea0073pep11.3 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Identification of carbonic anhydrases III and IX in the adipose microenvironment of adrenocortical carcinoma

Fei Laura , Cantini Giulia , Nocentini Alessio , Canu Letizia , Nardini Patrizia , De Filpo Giuseppina , Ercolino Tonino , Nesi Gabriella , Maggi Mario , Bani Daniele , Mannelli Massimo , Supuran Claudiu T , Luconi Michaela

The adipose tissue (AT) is an important endocrine organ. Upon energy imbalance, the adipose cells become dysfunctional, supporting the development of metabolic pathologies and tumours. The adipose cell is among the main actor of the tumor microenvironment, and is able to establish a crosstalk with the cancer cell resulting in a reciprocal reprogramming. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy affecting the adrenal cortex. In the most aggressive forms, can...

ea0073pep11.4 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Computerized tomography texture analysis in pheochromocytoma: correlation with clinical, biochemical, and histopathological data

Di Dalmazi Guido , Vara Giulio , Leo Antonio De , Paccapelo Alexandro , Tucci Lorenzo , Vicennati Valentina , Selva Saverio , Balacchi Caterina , Santini Donatella , Minni Francesco , Pagotto Uberto , Golfieri Rita , Mosconi Cristina

Computerized tomography (CT) texture analysis (TA) provides a valuable amount of quantitative data on single voxels and their relationship in a target lesions, giving additional value to the CT scan. CTTA has been applied to several oncologic diseases. We aimed to correlate the data derived from CTTA of pheochromocytoma to clinical, biochemical and histopathological data in 30 consecutive patients. Pheochromocytoma was confirmed at histology. The CTTA was performed on unenhanc...

ea0073pep11.5 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Pre-operative hypercortisolism and post-operative adrenal insufficiency in pheochromocytomas: a single center retrospective analysis of 168 patients

Kourti Eleni , Fideline Bonnet , Vaczlavik Anna , Libe Rossella , Bessiene Laura , Guignat Laurence , Sibony Mathilde , Groussin Lionel , Dousset Bertrand , Assié Guillaume , Bertherat Jerome

IntroductionPheochromocytoma might be associated with hypercortisolism and post-operative adrenal insufficiency. The aim of this study is to determine the frequency of cortisol dysregulation before and after pheochromocytoma surgery.MethodsSingle center retrospective study of consecutive pheochromocytoma patients investigated in the Endocrinology department of Cochin Hospital before and after surgery from 200...

ea0073pep11.6 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Increased risk of cardiometabolic disease in patients with benign adrenal tumours with and without cortisol excess: a case–control study

Prete Alessandro , Subramanian Anuradhaa , Bancos Irina , Sitch Alice J , Chortis Vasileios , Lang Katharina , Tsagarakis Stylianos , Macech Magdalena , Delivanis Danae A , O’Reilly Michael W , Masjkur Jimmy R , Quinkler Marcus , Ueland Grethe Å , Dennedy M Conall , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young William F Jr , Manolopoulos Konstantinos N , Ambroziak Urszula , Vassiliadi Dimitra A , Nirantharakumar Krishnarajah , Arlt Wiebke

BackgroundBenign adrenocortical tumours are found in 3–5% of adults and can be non-functioning (NFAT) or associated with cortisol excess. The latter group divides into patients with clinically overt signs (adrenal Cushing’s syndrome, CS) and patients lacking CS signs (mild autonomous cortisol excess, MACE). The 1 mg-overnight dexamethasone suppression test (DST) further differentiates MACE into MACE-1 (possible MACE; post-DST cortisol 50–1...

ea0073pep11.7 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

All-cause mortality in adrenal insufficiency patients with primary and secondary adrenal insufficiency

Ngaosuwan Kanchana , Johnston Desmond , Godsland Ian , Cox Jeremy , Majeed Azeem , Quint Jennifer , Oliver Nick , Robinson Stephen

BackgroundIncreased mortality risk of patients with adrenal insufficiency has been inconsistently reported. This might have resulted from the disparity of time and place of clinical care between the study patients and reference population. Also, data of patients with secondary adrenal insufficiency was limited as majority focused on other types of pituitary disorders. Therefore, we compared all-cause mortality of patients with primary and secondary adren...

ea0073pep11.8 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Urinary steroid profiling for adrenocortical carcinoma patients’ surveillance

Velikanova Ludmila , Vorokhobina Natalia , Shafigullina Zulfia , Kalugina Valentina , Malevanaya Ekaterina , Bohyan Vagan , Britvin Timur , Kushlinskii Nikolay

BackgroundThe aim of the study was to evaluate urine steroid metabolomics by gas chromatography–mass spectrometry (GC–MS) for the adrenocortical carcinoma (ACC) metastases` biomarkers detection in patients after the surgery.Patients and methods33 postoperative ACC patients were examined before and after the surgery. The median age was 47 years (41–60). The Weiss score was more than 3 points acc...