Endocrine Abstracts

Thyroid hormone (TH) homeostasis depends on the coordination of several key events to maintain proper local TH signaling, including iodide uptake, hormone synthesis, metabolism, and elimination. The three isoenzymes, Deiodinases (DIO1-3), are essential components of hormone metabolism. They catalyze iodide release the outer and/or inner ring of TH structure to convert between their active and inactive forms. The activity of DIOs has been identified as an important endpoint reg...

IntroductionAlemtuzumab is an anti-CD52 antibody, leading to lysis and transient depletion of T and B lymphocytes. Its therapeutic effect is mediated by the alteration in immune repertoire that accompanies subsequent lymphocyte reconstitution. It is mainly used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Common side effects are autoimmune diseases, including thyroid disease (>40%), immune thrombocytopenia (IT...

BackgroundDyslipidemia is relevant association of hypothyroidism and consists of raised levels of total cholesterol, apolipoprotein B, triglycerides, low density lipoprotein (LDL) cholesterol, and reduced levels of high density lipoprotein (HDL) cholesterol.Thyroid hormones also have a role in modulating glucose metabolism and insulin resistance. The aim of study was to assess glycemic status, Homeostasis model assessment–estimated Insulin Resistanc...

Background and aimAutoimmune thyroiditis (AIT) is one of the most common autoimmune diseases, affecting more than 10% of females and 2% of males in the overall population. Clinical evidence suggests that oral supplementation with myo-inositol (MI) and vitamin D (VD) is useful in the treatment of AIT. MI is a carbocyclic polyol precursor of phosphoinositide synthesis. It is involved in cell signaling and, precisely, as a second messenger regulating the ac...

IntroductionA strong association between autoimmune atrophic gastritis and other autoimmune disorders has been well documented. The prevalence of gastric mucosa alterations in patients with thyroid autoimmunity is not well known. The aim of our study was to assess the prevalence of intestinal metaplasia in patients with Graves’ disease (GD) and positive anti-parietal cell antibodies (APCA).Methods<p class=...

BackgroundGraves’ Disease (GD) is characterized by production of stimulating autoantibodies to thyrotropin receptor resulting in hyperthyroidism. Hyperthyroidism is associated with insulin resistance, hyperglycemia and ketosis. Our aim was to evaluate if single nucleotide polymorphism (SNP) in pro-inflammatory cytokines contributes to dysglycemia in GD.MethodsWe evaluated 98 patients with Graves’ di...

The impact of novel coronavirus (COVID-19) infection in adult patients with endocrine diseases is well established, with the evidence showing a link between endocrine pathology and disease severity (A. Badawi, S.G. Ryoo, 2016, J. Yang et al, 2020, S. Cianfarani, A. Brancatella, 2020). The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay (L. Scappaticcio, et al, 2...

IntroductionDiagnostics of thyroid dysfunctions is frequently based on the measurements of TSH serum concentration only. Currently, due to a tendency to minimize stressful situations for a child (such as venipuncture to take a blood sample), some tests (i.e. TSH assessment) are performed at the Primary Healthcare Centre while other diagnostic tests (e.g. during an infection) are run. If TSH serum concentration is outside the reference range, it leads to ...