Endocrine Abstracts

IntroductionInsulinomas are the most common functional neuroendocrine tumours of the pancreas. Because previous data on the long-term prognosis of insulinoma patients are scarce, we wanted to study the morbidity and mortality in Finnish patients previously treated for an insulinoma.Patients and methodsThe Finnish insulinoma register consists of all adult patients diagnosed with an insulinoma in Finland during...

BackgroundIn about 2/3 of pheochromocytoma patients, no pathogenic germline variant can be identified that might be responsible for the onset of the disease. However, in many patients, we observe the repeated appearance of one or more common polymorphisms in the gene RET. Each of them has been shown to be of no significance for pheochromocytoma and multiple endocrine neoplasm type 2 development, when analysed individually. We decided to test whe...

BackgroundCushing’s syndrome due to ectopic ACTH secretion only accounts for 10% of all cases of Cushing’s syndrome and is most often associated with pulmonary neuro-endocrine tumors. Treatment of ectopic ACTH syndrome is predominantly surgical with resection of the tumor. Following resolution of hypercortisolism, previously subclinical Pneumocystis jiroveci infection can become overt due to restored immune response.Clini...

IntroductionParathyroid carcinoma is a very rare phenomenon with an estimated prevalence of 0.005% of all cancers. There have been fewer than ten cases of parathyroid carcinoma in pregnancy previously reported in literature. Clinical features are similar to primary hyperparathyroidism and the diagnosis is usually made on surgery or histology. We present a unique case of parathyroid carcinoma in pregnancy where ventricular bigeminy was the presenting feat...

Background20–30% of patients with metastatic small intestine neuroendocrine tumours (SI-NETs) suffer from carcinoid syndrome (CS), i.e. diarrhea, flushing, and bronchospasm. Of these, 25–50% develop carcinoid heart disease (CHD) characterized by valve fibrosis and right heart failure. There are no early predictive markers of CHD, which typically is diagnosed in the advanced stage.Aims of the studyTo...

Pancreatic neuroendocrine tumors (panNETs) comprise several neoplasms in which a precise diagnosis and therapeutic treatment are hampered by their diversity and heterogeneity which in turn, hind the identification of common molecular signatures and the development of efficient therapeutic approaches. Subsequently, there are no clinical, biochemical, anatomopathological, immunohistochemical or molecular features capable to currently predict either tumor prognosis or post-surgic...

BackgroundHypercalcaemia is commonly encountered during clinical practice. SCCOHT is a rare ovarian malignancy typically found in young women. In two thirds of patients, it causes a paraneoplastic hypercalcaemia which is usually asymptomatic.Case ReportA thirty-seven-year-old lady, presented to casualty with a one -week history of worsening nausea, vomiting, anorexia, abdominal pain, polydipsia, and polyuria....

IntroductionBased on the evidence available back then, in 2015 we developed a provincial multicenter protocol for screening and follow up of no-index patients with SDHB and SDHC mutations.Objectives1. To evaluate the performance of the protocol designed for the follow-up of asymptomatic SDHB and C carriers. 2. To describe the penetrance of manifestations associated with hereditary PGL-FEO syndromes type 3 and...