Endocrine Abstracts

IntroductionAlthough most patients with COVID-19 have mild symptoms, some develop severe manifestations of the disease, leading to hospitalization and death. Previous studies reported that calcium played a central role in viral infections and replicative mechanisms of SARS-CoV. Hypocalcemia is a common finding among these patients. The aim of this study was to investigate the prevalence of hypocalcemia in a population of COVID-19 patients and to evaluate...

IntroductionAdequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Low levels of micronutrients are associated with adverse clinical outcomes during viral infections. Vitamin D improves the physical barrier against the virus and stimulates the production of antimicrobial peptides. It can prevent cytokine storms by reducing the production of inflammatory cytokines....

We have previously shown that Low T3 syndrome is associated with serum markers, radiologic and clinical scores of COVID-19 severity and it can be considered as a novel biomarker of the severity of the disease (Endocrine Abstracts 2020, 70 AEP1091). With the aim to analyze the mechanisms that are at the basis of this condition as well as the pathways involved, we applied an integrative approach of multi-omics data. We performed: i) multiplex cytokine assay, using the B...

ContextThyroiditis is defined as an inflammation of the thyroid gland. There are several kinds of thyroiditis, and they can be associated with either increased, decreased, or normal thyroid function (triphasic-course). Subacute granulomatous thyroiditis, also known as subacute thyroiditis (SAT), giant-cell thyroiditis, or de Quervain thyroiditis, is a self-limited thyroiditis characterized by neck pain and thyroid dysfunction. Generally, it is preceded b...

ContextThe effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with Euthyroid-Sick-Syndrome-ESS, thyrotoxicosis or suppression of thyroid-function-tests (TFTs) reported which can lead to inadequate diagnoses and treatments.ObjectiveThe aim of this case report is to describe, for the first time, a possible interference of macro-TSH in a patient with SARS-CoV2 and thy...

IntroductionWorldwide, 100 million people have been diagnosed with COVID-19. Patients with adrenal insufficiency (AI) are assumed, on the basis of expert opinion, to be at higher risk of infection.AimTo determine the patient reported incidence and potential risk factors of infection with COVID-19, for patients diagnosed with AI.MethodA 42 item questionnaire (inclu...

Beyond the huge impact on physical health, coronavirus disease-19 (COVID-19) epidemic represents a significant psychological stressor, causing effects on mental health. The psychological distress of the epidemic and consequent mass quarantine on patients with hypocortisolism, particularly frail and vulnerable to infections and stress, is unknown. The current multicentre, web-survey-based, case-control study evaluated the psychological impact of COVID-19 quarantine in a large c...

IntroductionIn response to the COVID-19 pandemic, delivery of medical education has transitioned from predominantly in-person teaching to virtual platforms. Simulation-based learning is a successful teaching modality to develop clinicians’ knowledge and skill, while safeguarding patients. Simulation has traditionally been performed via face-to-face role play, however many of its principles can be adapted for remote use. We explored the effectiveness...