Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Presented Eposters

Presented ePosters 15: Late Breaking

ea0073pep15.1 | Presented ePosters 15: Late Breaking | ECE2021

Diabetic euglycemic ketoacidosis in newly diagnosed type 1 diabetes mellitus during A ketogenic diet

Erdogan Beril Turan , Durmaz Himmet , Bestepe Nagihan , Ogmen Berna , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

BackgroundDiabetic ketoacidosis (DKA) is one of the most serious complications of diabetes. It is characterised by the triad of hyperglycemia (blood sugar >250 mg/dl), ketosis and metabolic acidosis (arterial pH CaseA 22-year-old female patient appl...

ea0073pep15.2 | Presented ePosters 15: Late Breaking | ECE2021

Monocarboxylate transporter 8 deficiency leads to autophagy-induced persistent cathepsin-mediated thyroglobulin processing triggered by insufficient L-type amino acid transporter 2 functionality

Venugopalan Vaishnavi , Al-Hashimi Alaa , Weber Jonas , Rehders Maren , Golchert Janine , Homuth Georg , Verrey Francois , Kirstein Janine , Heuer Heike , Schweizer Ulrich , Wirth Eva , Brix Klaudia

The thyroid gland functions in supplying thyroid hormones (TH) to the body periphery, which is enabled by cathepsin-mediated thyroglobulin proteolysis and TH translocation across membranes by the Mct8, Mct10, and Lat2 transporters. Previously, we showed that cathepsin K-deficient mice feature normal thyroid phenotypes which is, in part, due to the functional compensation through cathepsin L upregulation that is independent of the classical hypothalamus–pituitary–thyr...

ea0073pep15.3 | Presented ePosters 15: Late Breaking | ECE2021

TGF-β increase caspase activation and migration in typical bronchial carcinoids

Patricia Borges de Souza , Gagliardi Irene , Martelli Mariano , Ambrosio Maria Rosaria , Maria Chiara Zatelli

IntroductionTypical bronchial carcinoids (TBC) are rare well-differentiated neuroendocrine neoplasms (NEN) of the lung whose management can still be very challenging. In fact, the gold-standard treatment for TBC is total resection of the primary tumour; however, in case of metastatic disease adjuvant therapy with the mTOR inhibitor everolimus (eve) might be recommended. Unfortunately, prognosis may be very poor in cases showing moderate response rates to...

ea0073pep15.4 | Presented ePosters 15: Late Breaking | ECE2021

Selection of the most effective genetic tests for the diabetes mellitus risk prediction in Belarus

Lushchyk Maxim , Ameliyanovich Maxim , Tuzava Hanna , Mosse Irma , Danilova Larissa I.

Introduction and backgroundAccording to world diabetes-focused organizations (EASD and IDF) the number of patients with type 2 diabetes mellitus (T2DM) and obesity is increasing tremendously all over the world. The FTO gene (Fat mass and obesity-associated gene) was noticed during GWAS-study at 2007, when it’s multiple polymorphic variants were detected, many of which were associated with obesity and T2DM. Significant differences in allele prevalenc...

ea0073pep15.5 | Presented ePosters 15: Late Breaking | ECE2021

Pheochromocytoma secreting IL-6; an atypical presentation

Laura García María , Lisdero Ana Paula , González Pernas Mariana , Speroni Romina , Segarra Ana , Otero Jimena , Genovesi Elbio , Belli Susana , Giselle Mumbach Aizhar

Pheochromocytoma (PCC) is a rare tumor that arises from the adrenal medulla, usually presents with headache, sweating and palpitations due to excessive catecholamine release. However, PCC may secrete neuropeptides, hormones and cytokines, such as interleukin-6 (IL-6)) resulting in unusual clinical manifestations. A 48-year-old woman with a previous history of type 1 neurofibromatosis (NF1) and hypertension was referred to discarded PCC. Laboratory tests revealed leukocytosis a...

ea0073pep15.6 | Presented ePosters 15: Late Breaking | ECE2021

Association between diabetic retinopathy, telomere length and serum proteasome concentration in type 1 diabetes: cross-sectional study in Latvia and Lithuania

Svikle Zane , Tiscuka Angelina , Voitovica Liga , Pahirko Leonora , Baumane Kristine , Kardonaite Deimante , Kazokaite Mintaute , Lina [email protected] , Laura Daugintyte-Petrusiene , Balciuniene Jurate , Sokolovska Jelizaveta

BackgroundDiabetic retinopathy is the leading cause of blindness in working-age adults in developed world. Derangements of ubiquitine-proteasome system and telomere length have been associated with microangiopathy in diabetes. Until now, limited data are available on above markers in diabetic retinopathy in type 1 diabetes (T1D).AimThe aim of this work was to compare serum proteasome concentration and telomer...

ea0073pep15.7 | Presented ePosters 15: Late Breaking | ECE2021

Adherence to levothyroxine treatment and factors related with adherence in hypothyroid patients

Dirikoc Ahmet , Genc Birgul , Ozdemir Didem , Tam Abbas Ali , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

ObjectivesAdherence to treatment is one of the most important parameters that affect the success of the treatment in hypothyroidism. We aimed to evaluate the use and adherence to treatment and determine the factors that are related to adherence in patients on levothyroxine therapy.Materials and MethodsPatients older than 18 years old and using levothyroxine for hypothyroidism were recruited. Demographical, so...

ea0073pep15.8 | Presented ePosters 15: Late Breaking | ECE2021

Aggressive follicular thyroid carcinoma in a patient with Carney complex

Maria Fernandez-Trujillo-Comenge Paula , Hernandez-Lazaro Alba , de Leon-Durango Ricardo , Kuzior Agnieszka , Nivelo-Rivadeneira Manuel Esteban , Santana-Suarez Ana Delia , Arnas-Leon Claudia , Acosta-Calero Carmen , Gonzalez-Diaz Paula , Martinez-Martin Francisco Javier

IntroductionCarney Complex is a rare syndrome characterized by lentiginosis cutis and/or blue nevi, multiple endocrine neoplasia and non-endocrine tumors (cutaneous, mucosal, mammary or cardiac myxomata, bone osteochondromyxoma, psammomatous melanotic schwannoma, multiple ovarian cysts, multiple mammary ductal adenoma). Most cases are familiar, with autosomal dominant heredity and penetrance close to 100%. It is caused by a variety of mutations that acti...