ECE2021 Audio Eposter Presentations Calcium and Bone (75 abstracts)
Relationship between muscle function and trabecular bone score (TBS) in Type 2 diabetes mellitus
Maria Hayon Ponce 1 , David Blanquez Martinez 2 , Mª del Carmen Serrano Laguna 1 , Maria Dolores Aviles Perez 1 , Beatriz Garcia Fontana 1 & Manuel Muñoz Torres 1
1Bone Metabolic Unit, Endocrinology and Nutrition Division. Universitary Hospital Clínico San Cecilio., Granada, Spain; 2Hospital Pharmacy Division. Universitary Hospital Clínico San Cecilio., Granada, Spain
Context
The incidence of Type 2 diabetes mellitus (T2DM) is increasing and muscle strength and function are reported to be decreased in patients with T2DM compared to healthy controls.However, the relation between bone and muscle remain unclear.
Objective
Our aims was to examine bone health parameters [by Dual energy X-ray absorptiometry (DXA) and trabecular bone score (TBS)] and muscle strength (by hand grip) in T2DM patients.
Design
Cross-sectional observational study
Setting
Tertiary care hospital
Patients
60 T2DM patients (60% males and 40% postmenopausal women) aged 49–85 years.
Measures
Anthropometric and metabolic parameters were determined. Bone mineral density (BMD) of the lumbar spine(LS), femoral neck(FN) and total hip(TH) and TBS were assessed using DXA and TBS iNsight Software. Hand grip strength (kg/cm2) was measured with a jamar hydraulic hand dynamometer (5030j1; jackson, MI).Handgrip strength < 30 kg (male) or < 20 kg (female) was defined as low muscle strength. Data were analysed using SPSS 25.0.
Results
60 patients with T2DM were studied. Mean age of T2DM patients was 66.3 ± 8.31 years. Mean HbA1C was 7.7 ± 1.1%. 73.3% had poorly glycemic control ( HbA1c > 7.5%).95.8% of female and 91.7% of male had low muscle strength.Hand-grip strength was positively correlated with TBS (R = 0.321, P < 0.01) and with TH- BMD (R = 0.268, P < 0.05).
Conclusions
Our study show that the reduction of muscle strength was significantly associated with decreased bone mass and deteriorated bone microarchitecture in T2DM patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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