ECE2021 Audio Eposter Presentations Calcium and Bone (75 abstracts)
Height loss is almost 3 times more correlated with trabecular bone score than with bone mineral density
Dan Peretianu 1 , Adrian Sarbu 2 , Catalin Gavrila 2 , Serban Motoiu 1 , Mihaela Stanciu 3 , Aurelian Ranetti 4 & Denis Paduraru 5
1Medical Center Povernei, Endocrinology, Bucharest, Romania; 2Medical Center ’Sana’, DEXA, Bucharest, Romania; 3Faculty of Medicine ’Victor Papilian’, Endocrinology, Sibiu, Romania; 4Central Military Hospital ’Carol Davila’, Endocrinology, Bucharest, Romania; 5Institute of Sportive Medicine, Laboratory of Physiology, Bucharest, Romania
Aim
To show that height loss is more correlated with vetebral micoarchitecture than with Bone Mineral Density (BMD).
Material and method
A. DEXA. Made with a GE-Lunar Prodigy Pro # 50 0074. Vertebral microarchitecture was investigated by Trabecular Bone Score (TBS). TBS software: TBS iNsight, version 3.0.2.0. B. Patients. 784 patients, 737 (94%) women, 47 men. Only 38 under 50 years. Age average: 66.04 years. Women: 65.8 years, men 69.89 years. C. Height measurement. At the time of DEXA analysis, each patient’s height was measured (centimeters). Patients were asked to appreciate the difference in height compared to a previous age to which they can relate. D. Statistical analysis. Student ta test was used for differences. Linear correlation test (r) was used for correlations.
Results
1. Diagnosis of osteoporosis. BMD scores led to the classic diagnosis of osteoporosis in only 28.2% of patients. TBS T scores suggested the diagnosis of osteoporosis in 71.56% of patients (Table).
| BMD-T score | |||||
| Normal | Osteopenia | Osteoporosis | Total | ||
| TBS-T score | Normal | 33 | 11 | 5 | 49 |
| 4.2% | 1.4% | 0.6% | 6.3% | ||
| Partial degraded -1 – 2.5 (osteopenia) | 63 | 81 | 30 | 174 | |
| 8.0% | 10.3% | 3.8% | 22.2% | ||
| Degraded <-2.5 (osteoporosis) | 121 | 254 | 186 | 561 | |
| 15.43% | 32.40% | 23.72% | 71.56% | ||
| Total | 217 | 346 | 221 | 784 | |
| 27.7% | 44.1% | 28.2% | 100.0% | ||
The concordant diagnosis of osteoporosis by the intersection of BMD and TBS scores occurred in only 23.72% of patients. 2. Decreasing height. a. Average: 3.49 cm. Women loss height = 3.49 cm, Men loss height = 3.404 cm. Maximum average loss was recorded at over 85 years = 7.4 cm. The minimum mean loss was found at < 45 years = 0.8 cm. b. Correlations between height decrease and DEXA values. The correlation of the decrease in height with the T score of the BMD was r = 0.1409. The correlation of height decrease with TBS was ’r’ = 0.4019. Both correlations generate P < 0.001. However, the value ’r’ for the correlation with TBS was 2.85 times higher.
Conclusions
1. Vertebral compression is correlated with age, higher in women than in men. 2. Patients lose up to 7.4 cm in the 8th decade of life. 3. TBS is more correlated with vertebral microarchitecture and decrease in height with age compared to BMD, since the correlation ’r’ between TBS values and height decrease and the correlation between height decrease and BMD is almost 3 times higher.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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