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Endocrine Abstracts (2021) 73 AEP171 | DOI: 10.1530/endoabs.73.AEP171

ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)

Risk factors of cardiovascular autonomic neuropathy in patients with prediabetes and coronary artery disease

Olena Stepura1, 2, Nadiia Zherdova1, 2, Georgy Manko vs ky3 & Borys Mankovsky1, 2


1State Scientific Institution ’Center for Innovative Medical Technologies of the National Academy of Sciences of Ukraine’, Department of diagnosis and treatment of metabolic diseases, Kyiv, Ukraine; 2P.L. Shupyk National Medical Academy of Postgraduate Education, Department of Diabetology, Kyiv, Ukraine; 3Scientific and Practical Medical Center of Pediatric Cardiology and Cardiac Surgery, Department for adults, Kyiv, Ukraine


Background

Cardiovascular autonomic neuropathy (CAN) is a chronic complication associated with high risk of cardiovascular morbidity and mortality either in patients with diabetes mellitus and prediabetes. However, risk factors of CAN in patients with prediabetes and coronary artery disease (CAD) was not fully investigated.

Aims

The aim of this study was to investigate risk factors of CAN in patients with prediabetes and CAD.

Materials and methods

We examined 32 patients with prediabetes and angiography confirmed stenosis of coronary arteries, 20 males and 12 females (aged 61.44 ± 1.92 years, HbA1c – 5.87 ± 0.1%) (data are presented everywhere as mean ± sem). All patients were performed cardiovascular autonomic reflex tests (CARTs) by Ewing. The diagnosis of CAN was confirmed in patients with 2 and more positive tests. The statistical analysis was performed using SPSS statistical package version 25.0 for Windows.

Results

CAN detected by 2 abnormal tests of CARTs was diagnosed in 40.6% patients with prediabetes and CAD, by 3 abnormal tests – in 43.8%. We found positive correlation between the total score of CARTs: and levels of total cholesterol, (r = 0.44, P < 0.05), fasting insulin, (r = 0.41, P < 0.05), HOMA-IR (r = 0.46, P < 0.01), heart rate (r = 0.4, P < 0.05), and negative correlation with glomerular filtration rate, (r = –0.39, P < 0.05). We found that CAN diagnosed by 2 abnormal tests of CARTs had positive correlation with fasting glucose, (r = 0.36, P < 0.05) and HbA1c (r = 0.4, P < 0.05), but if there was no correlation of CAN detected by 3 abnormal tests of CARTs with these parameters.

Conclusion

CAN is the common complication of prediabetes and there are some risk factors for its development revealed in our study.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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