ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Increase in PUFA and in protein intake leads to reduction of liver fat independently of weight loss in 12 months: the NutriAct trial
Laura Pletsch-Borba 1 , Charlotte Wernicke 1 , Konstantina Apostoloupoulou 1 , Dominik Spira 1 , Anne Pohrt 1 , Silke Hornemann 2 , Christiana Gerbracht 2 , Andreas Pfeiffer 1 , Joachim Spranger 1 & Knut Mai 1
1Endokrinologie Und Stoffwechsel, Berlin, Germany; 2Human Study Center, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
Background
Long-term effects of an increase in unsaturated fatty acids and protein on changes in intrahepatocellular lipids (IHL) are still unclear. We aimed to explore the impact of changes in individual macronutrients on IHL changes within the NutriAct intervention trial over 12 months in middle-aged and elderly subjects (50–80 yrs) at risk for age-related diseases.
Design
In the NutriAct randomized controlled trial, the effect of a high-protein and high-UFA diet was compared to the dietary recommendations of the German Nutrition Society. Individuals who completed 3-day food records and had IHL data both at baseline and at month 12 were included in this study. Intake (E%) of each macronutrient was calculated and IHL was measured by proton density fat fraction spectroscopy. Associations between changes in macronutrients intake and changes in IHL were analyzed, including mediation analysis to identify the role of weight loss as a mediator.
Results
248 participants were included in the analyses (34% male, median age 66y). BMI and IHL improved in both intervention groups in 12 months (both P < 0.01) and differed significantly between groups (P < 0.05). Participants with higher increase in protein and PUFA intake and a greater decrease in carbohydrate intake showed a stronger improvement in IHL (P < 0.05). Changes in protein, carbohydrate and PUFA, and IHL improvement are mediated by BMI changes. Increase in protein (P = 0.05) and in PUFA (P = 0.01) intake was also directly associated to IHL improvement (not BMI change-mediated).
Conclusions
Increase in intake of protein and PUFA, and decrease in carbohydrates intake led to IHL reduction after 12 months in middle-aged and elderly subjects. While these effects are partially mediated by weight loss, there is also a direct effect between increase in protein (trend) and in PUFA and IHL improvement. These results give insight into the understanding of a high-UFA diet on IHL changes in a long-term dietary intervention.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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