ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Visceral adiposity index and atherogenic index of plasma: Simple markers of insulin resistance in type 2 diabetic patients
Asma Kardi 1 , Ibtissem Oueslati 1 , Meriem Yazidi 1 , Bassem Hammami 2 , Fatma Boukhayatia 1 , Fatma Chaker 1 , Moncef Feki 2 & Melika Chihaoui 1
1La Rabta hospital, university of Tunis El Manar, Faculty of Medicine, Endocrinology, Tunis, Tunisia; 2La Rabta Hospital, University of Tunis El Manar, Faculty of Medicine, Laboratory of Biochemistry, Tunis, Tunisia
Introduction
Homeostasis model assessment for insulin resistance (HOMA-IR) is widely used as a marker of insulin resistance. However, it reminds an expensive maker requiring insulin dosage. Several studies tried to found simple alternative predictors of insulin resistance such as triglycerides to HDL-C ratio with conflicting reported findings. The aim of our study was to investigate the usefulness of the atherogenic index of plasma (AIP) and the visceral adiposity index (VAI) as insulin resistance markers.
Methods
We conducted a transversal study in 55 patients with type 2 diabetes mellitus treated with oral antidiabetic drugs. All participants had physical examination and laboratory investigations. HOMA-IR index, AIP and VAI were calculated.
Results
The study population included 29 women and 26 men. Their mean age was 54.6 ± 10.1 years. Seventy seven percent of patients had well-controlled diabetes. The mean of fasting insulin levels was 9.7 ± 5.1 miu/l. Sixty two percent of patients had insulin resistance. The mean of VAI was 2.5 ± 1.7 with extremes of 0.46 and 8.75. According to VAI level, adipose tissue dysfunction was absent, mild, moderate, and severe in 46, 9, 25 and 20% of patients, respectively. The VAI was positively correlated with insulin level (r = 0.557; P < 103) and HOMA-IR index (r = 0.569; P < 10–3). Patients with insulin resistance had significantly higher VAI than those without insulin resistance (P = 0.033). The AIP demonstrated a low risk in 47%, an intermediate risk in 15% and a high risk in 38% of patients. This index was positively correlated with insulin level (r = 0.432; P = 0.001) and HOMA-IR index (r = 0.468; P < 10–3). However, no significant difference was found between patients with or without insulin resistance (P = 0.069).
Conclusion
AIP and VAI are commonly used as markers of atherosclerosis and cardiovascular risk. However, our results demonstrated that they could be used as simple and inexpensive markers of insulin resistance instead of insulin dosage and HOMA-IR index.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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