Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2021) 73 AEP283 | DOI: 10.1530/endoabs.73.AEP283

ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)

Diabetic nephropathy in absence of diabetic retinopathy in type 2 diabetes mellitus patients

Rahma Khalaf , Zohra Hadj Ali , Yosra Htira & Faika Ben Mami

National Institute of Nutrition, Tunis, Tunisia


There is a well-recognized association between diabetic retinopathy (DN) and diabetic nephropathy (DN), in which nephropathy without retinopathy is rare but retinopathy without nephropathy is common.


To highlight the discordance between retinopathy and nephropathy and describe a series of patients with diabetic nephropathy who had no evidence of diabetic retinopathy.


110 type 2 diabetes patients with diabetic nephropathy were studied retrospectively. Patients with clinical suspicion of non diabetic nephropathy were excluded. The patient’s age, gender, body mass index, duration of diabetes, glycosylated hemoglobin (HbA1c), low density lipoprotein cholesterol and presence of diabetic peripheral neuropathy were determined.


Of the study population, 31 patients (28.18%) had no evidence of diabetic retinopathy. 51.61% were male. Median age was 56 ± 15 years. The mean duration of diabetes was 12 ± 5 years, mean body mass index was 28.72 ± 4.3 kg/m2 (overweight), mean low density lipoprotein cholesterol was 1.25 ± 0.3 g/l. All patients had poor glycemic control with a mean HbA1c of 10.3%, 51.61% had treated hypertension, 32.26% had diabetic peripheral neuropathy. 58.06% had albuminuria without renal failure, 41.92% had renal failure without albuminuria: mean estimated glomerular filtration rate (eGFR) was 50 lm/min/1.73 m2.


We have identified a subset of patients with diabetic nephropathy but who are protected from retinopathy. It is possible that there is an extreme phenotype of diabetic patients with unaffected eyes who carry genes protecting against DR.

Volume 73

European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

European Society of Endocrinology 

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