ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Vitamin D levels in a cohort of patients with SARS-CoV-2 infection and relationship with disease outcome
Kostoglou Athanasiou Ifigenia 1 , Nikolakopoulou Sofia 2 , Alexandra Konstantinou 2 , Lambros Athanassiou 2 , Alexandros Spyrantis 2 , Olga-Maria Spyropoulou 2 , Olga Mascha 3 , Charilaos Samaras 2 , Ioannis Bliziotis 2 & Panagiotis Athanassiou 4
1Asclepeion Hospital, Voula, Department of Endocrinology, Athens, Greece; 2Asclepeion Hospital, Voula, Covid Department, Greece; 3Asclepeion Hospital, Voula, Department of Biochemistry, Athens, Greece; 4Saint Paul’s Hospital, Department of Rheumatology, Thessaloniki, Greece
Infection with the new SARS-CoV-2 or Covid-19 virus has a variable course. It may run as a mild disease or may cause severe pneumonia necessitating hospitalization. Vitamin D has immunostimulatory action and causes the release of substances necessary for combating an infection. Therefore, the relationship of vitamin D with the SARS-CoV-2 virus is under scientific evaluation. The aim was to measure vitamin D levels in a cohort of patients hospitalized with SARS-CoV-2 infection. In a cohort of 43 patients, 20 male and 23 female, hospitalized with the SARS-CoV-2 infection 25(OH)D3 levels were measured. 25(OH)D3 levels were also measured in a group of control subjects. The patients were classified in 4 groups, a group with uncompromised respiratory function (n = 17 patients), a group with mild respiratory insufficiency (n = 12), a group with severe respiratory insufficiency (n = 5) and a group with severe respiratory insufficiency requiring intubation (n = 8). For the evaluation of the results of the present study 25(OH)D3 levels were classified as deficiency (0–10 ng/ml), insufficiency (10–20 ng/ml) and sufficiency > 20 ng/ml. 25(OH)D3 levels in the SARS-CoV-2 patients were 16.16 ± 1.55 ng/ml (mean ± SEM) as compared to those in the control group, 27.28 ± 1.94 ng/ml (P < 0.001, Student’s t test). Within the group 37 patients finally survived the infection while 6 died either during hospitalization or immediately thereafter. The outcome of the infection, i.e. respiratory insufficiency or need for intubation was found to be related to the levels of 25(OH)D3 (P = 0.003, chi-square test). It appears that vitamin D deficiency as assessed by the measurement of 25(OH)D3 levels is prevalent in patients with severe SARS-CoV-2 infection requiring hospitalization. Vitamin D levels appear also to be related to the outcome of the infection. This result is in accordance with the immunostimulatory action of vitamin D, an action known since the very early years of its discovery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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