ECE2021 Audio Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (223 abstracts)
Mucormycosis of the ENT sphere in diabetic subjects: About 4 observations
Mouna Bellakhdhar 1 , Takwa Belaid 1 , Ghammam Monia 1 , Ben Abdelkarim A 2 , Yaakoub A 3 , Mahrezi Abir 1 , kermani Wassim 1 , El Euch Koussay 2 , Fathallah A 3 & Abdelkafi Mohamed 1
1Department of Otolaryngology and Head and Neck Surgery, Farhat Hached Sousse Hospital, Tunisia; 2Endocrinology Department, Farhat hached Sousse Hospital, Tunisial; 3Parasitology mycology laboratory, Farhat Hached Sousse Hospital, Tunisia
Introduction
Mucormycosis is a rare and often fatal fungal infection which is caused by a group of molds called mucormycetes.It usually occurs in immunocompromised subjects and especially diabetics. The aim of our work is to specify the epidemiological, clinical and therapeutic characteristics of ENT mucormycosis in diabetic subjects.
Material and methods
A retrospective study included 4 diabetic patients with ENT mucormycosis diagnosed over 18-year period, from January 2000 to December 2017.
Results
The study involved two men and two women, aged between 40 and 77. All patients were diabetic. There were 2 cases of sinonasal mucormycosis, 1 case of rhinocerebral mucormycosis and 1 case of otologic involvement with cerebral extension. The diagnosis was based on anatomopathologic and mycologic examination. Culture isolated Rhizopus oryzae in 4 cases. The four patients were put on Amphotericin B associated with surgical curettage. One patient presented with an allergy to Amphotricin B, hence the use of its liposomal form. The evolution was good in 2 patients, one of whom retained a sequellar facial paralysis. A fatal issue occurred in 2 cases with otocerebral and rhinocerebral involvement.
Conclusion
Otorhinolaryngologic mucormycosis is a rare fungal infection. Rhinocerebral involvement is the most common clinical form and otological involvement is exceptional. The prognosis remains severe, depending mainly on the early diagnosis and treatment.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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