ECE2021 Audio Eposter Presentations Endocrine-Related Cancer (25 abstracts)
Assessment of different markers of ovarian reserve in women with differentiated thyroid cancer treated with radioactive iodine
Agnieszka Adamska 1 , Paulina Tomczuk-Bobik 1 , Anna Poplawska-Kita 1 , Katarzyna Siewko 1 , Angelika Buczynska 1 , Piotr Szumowski 2 , Łukasz Żukowski 2 , Janusz Myśliwiec 2 , Monika Zbucka-Krętowska 3 & Adam Krętowski 1
1Medical University of Bialystok, Department of Endocrinology, Diabetology and Internal Medicine, Bialystok, Poland; 2Medical University of Bialystok, Department of Nuclear Medicine, Bialystok, Poland; 3Medical University of Bialystok, Department of Gynecological Endocrinology and Adolescent Gynecology, Bialystok, Poland
Objective
It has been shown that treatment with radioactive iodine (RAI) of women with differentiated thyroid cancer (DTC) is connected with decreased serum concentration of anti-Müllerian hormone (AMH). To date, others markers connected with ovarian reserve have not been investigated yet. Therefore, the aim of the present study was to evaluate the effect of RAI on serum concentration of inhibin B, follicle stimulating hormone (FSH), AMH and antral follicle count (AFC) in women with DTC treated with RAI.
Materials and methods
We examined 25 women at the median age of 33, who were treated with single dose of RAI. Serum concentrations of inhibin B, FSH, AMH and AFC were assed at baseline and one year after RAI treatment.
Results
We found decreased serum levels of AMH (P = 0.02), inhibin B (P = 0.03) and AFC (P = 0.03) but not FSH (P = 0.23) one year after RAI treatment in comparison to the baseline.
Conclusions
We concluded that RAI treatment have signifficant impact on serum concentrations of AMH, inhibin B and AFC in premenopausal women with DCT, therefore this markers are usefull for assesment of ovarian reserve. Additionally, an assesment of ovarian reserve markers and the protection of oocytes, prior to treatment with RAI, should be considered in premenopausal women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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