Endocrine Abstracts

Background and aim

Hyperuricemia is linked to a variety of diseases such as atherosclerotic cardiovascular disease (ASCVD). There are controversial data concerning the significance of high-normal values of serum uric acid (SUA) in patients with T2DM and cardiovascular disease. The aim of the study is to assess SUA levels in Type 2 diabetes mellitus (T2DM) patients with ASCVD.

Patients and methods

This retrospective study was performed in 70 T2DM patients. All patients had treated hypertension and hypercholesterolemia. Participants were divided into 2 groups: Group1(G1) consists of 35 patients with ASCVD, Group2(G2) consists of 35 patients without ASCVD ASCVD includes previous acute coronary syndrome (myocardial infarction or unstable angina), coronary revascularization, stroke, transient ischaemic attack and peripheral arterial disease. Diabetes duration, SUA, glycosylated hemoglobin (HbA1c), LDL-cholesterol (LDL-C), triglyceride (TG), systolic and diastolic blood pressure and body mass index (BMI) were assessed.

Results

G1 consists of 22 men and 13 women. G2 consists of 22 women and 13 men. The mean age of the patients presented with and without ASCVD was 58.5 and 54.5 years respectively. SUA levels in ASCVD patients were higher compared to patients without ASCVD (341.5 µmol/l vs 272 µmol/l, P = 0.09). Diabetes duration was longer in G1 compared to G2 (13.5 vs 11.6 years, P = 0.06). HbA1c level and BMI did not statistically differ (11.15 % vs 11.08 %, P = 0.63; 36.31 vs 33.1 kg/m², P = 0.7 respectively). Values of systolic and diastolic blood pressure did not statistically differ in study groups (135 mmHg vs 129 mmHg, P = 0.5; 75 vs 80 mmHg, P = 0.26 respectively). TG levels were higher in G2 (3.44 mmol/l vs 1.9 mmol/l, P = 0.06) while LDLC levels did not statistically differ between two groups (2.99 vs 2.44 mmol/l, P = 0.9).

Conclusion

T2DM patients with ASCVD have higher SUA levels compared to group 2.HbA1c level, BMI, systolic and diastolic blood pressure and LDL-C did not statistically differ between two groups. Further studies are necessary to assess significance of SUA as an independent risk factor for development of ASCVD in T2DM patients.