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Endocrine Abstracts (2021) 73 AEP682 | DOI: 10.1530/endoabs.73.AEP682

ECE2021 Audio Eposter Presentations Thyroid (157 abstracts)

Relationship between vitamin D status and metabolic parameters in premenopausal women with autoimmune hypothyroidism

Oksana Chukur


Ternopil National Medical University, Internal Medicine №1, Ternopil, Ukraine


Background

Vitamin D deficiency is a global health problem. Nowadays is intensively studied the influence of vitamin D on the course of autoimmune diseases of the thyroid gland.

Objective

To study the relationship between vitamin D status and metabolic parameters in premenopausal women with autoimmune hypothyroidism.

Methods

146 premenopausal women with autoimmune hypothyroidism were examined. The mean age of patients was 46.8 ± 0.73 years. All women underwent anthropometric, general clinical, biochemical examinations, including determination of lipid and hydrocarbon metabolism, assessment of the functional state of the thyroid gland: TSH level, free thyroxine (FT4), free triiodothyronine (FT3), thyroid antibodies (TPOAb, TGAb). The collected data were statisstically analyzed using the Statistica 12 (р<0.05).

Results

The average level of TSH was 4.40 ± 0.21 uIU/ml; fТ3 –1.97 ± 0.09 pmol/l; fТ4 – 12.96 ± 0.37 pmol/l; TPOAb –112.87 ± 5.61 IU/ml; TGAb –152.25 ± 5.04 IU/ml, р<0.05. The mean level of 25 (OH) D in women with hypothyroidism was 16.42 ± 0.57 ng/ml, which corresponds to vitamin D deficiency (<20 ng/ml). Vitamin D deficiency was found in 78.8%, insufficiency in 17.1% of premenopausal women with hypothyroidism. There was a significantly strong (P <0.05) negative correlation between 25 (OH) D and TPOAb (r = -0.77), TSH (r = -0.72), TGAb (r = -0.33 ). Positive correlations of medium strength were found between 25 (OH) D and the level of fT3 (r = 0.46) and fT4 (r = 0.44), P <0.05. The body mass index averaged 29.4 ± 0.29 kg/m2. The mean level of glucose 5.49 ± 0.06 mmol/l, basal insulin level 28.63 ± 0.88 mIU/l, HOMA-IR 3.31 ± 0.08 (р<0.01). Hypercholesterolemia averaged 6.1 ± 0.12 mmol/l, cholesterol LDL 3.72 ± 0.07 mmol/l, cholesterol HDL 1.37 ± 0.02 mmol/l, TG 3.73 ± 0.09 mmol/l, atherogenic coefficient (AC) >3 was observed in 64%, P <0.01. Analysis of the relationships of metabolic parameters showed a significantly strong (P<0.05) negative correlation between 25 (OH) D with BMI (r = -0.74), AC (r = -0.65), the level of cholesterol HDL (r = -0.72), cholesterol LDL (r = -0.58), TG (r = -0.46), HOMA resistance index (r = -0.57).

Conclusion

Low vitamin D status is significantly associated with autoimmune thyroid dysfunction and determines the degree of metabolic disorders and cardiovascular risk in premenopausal women with autoimmune hypothyroidism.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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