Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2021) 73 EP156 | DOI: 10.1530/endoabs.73.EP156

ECE2021 Eposter Presentations Pituitary and Neuroendocrinology (32 abstracts)

Functional pituitary gonadotroph adenoma in male patients: a case study

Nanik Ram 1 , Sajjad Ali Khan 1 , Bhagwan Das 2 & Najmul Islam 1

1Aga Khan University Hospital, Department of Medicine, Section of Diabetes Mellitus, Metabolism and Endocrinology, Karachi, Pakistan; 2Cancer Foundation Hospital, Karachi, Pakistan


Pituitary gonadotroph adenomas are common but very rarely do they secrete biologically active luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There have been case studies reporting high sex hormones (testosterone/estrogen) in the presence of high or normal LH and FSH.

Case presentation

Here we report two cases who presented with visual disturbance and headache at a tertiary care hospital, Karachi, Pakistan. Brain imaging of both patients revealed a pituitary macroadenoma. Hornonal workup of our patients is shown below.

Hormonal workup of case 1 and case 2

Figure Legend: FSH, Follicle stimulating hormone; FT4, Free Thyroxine; LH, luteinizing hormone; MIU/ml, milli-international units per milliliter; ng/dl, nanogram per deciliter; ug/dl, microgram per deciliter; GH, Growth hormone; Both patients underwent transsphenoidal resection of the tumor and tissue histopathology confirmed pituitary adenoma. Postoperatively, improvement in hormonal profile was observed along with the resolution of visual disturbances and headaches.

Case 1 Case 2  
Normal values
FSH 36.66 4.97 13.61   1.4–15.4#160;MIU/ml
LH 7.09 0.99 4.45   1.2–7.8#160;MIU/ml
Testosterone 952.7 176.8  > 1500 20.14 193–740#160;ng/dl
Cortisol 2.60 7.40 12.60 11.10 4.3–22.4#160;ng/dl
FT4 0.69 1.65 0.84 0.88 0.89–1.76#160;ng/dl
Prolactin 12.40   36.80   3–14.7#160;ng/ml
GH  < 0.50 0.06 0.13   2.0–5.0#160;ng/ml


Thus, functional gonadotroph adenoma should be considered in the presence of elevated testosterone/estrogen and normal or elevated follicle-stimulating hormone (FSH)/ luteinizing hormone (LH). Early diagnosis leads to a better outcome.

Keyword: Pituitary Neoplasms, Gonadotrophs, Follicle Stimulating Hormone, Luteinizing Hormone, Adenoma, Testosterone

Volume 73

European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

European Society of Endocrinology 

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