Endocrine Abstracts

Background

In medical practice, there occurs an increasingly common pathology of various endocrine and not only these organs, which is known as multiple endocrine neoplasia – MEN syndrome, which, depending on the affected organs, is classified as MEN type 1, MEN type 2 and MEN type 3. Multiple endocrine neoplasia type 1 (MEN-1, Wermer syndrome) is a rare hereditary disease with an autosomal dominant type of inheritance characterised by high penetrance and the presence of hyperplasia and neoplasia in at least two different endocrine organs. The purpose of the study is to to investigate the features of diagnosis and treatment tactics of the MEN syndrome type 1 based on a clinical case.

Materials and methods

We examined Patient K. born in 1979. Diagnostics methods used in this case were: laboratory – determination of the level of prolactin, vasoactive intestinal peptide, calcitonin, vitamin D3 (25-OH) D, parathormone, calcium, aldosterone, chromatographic A; and instrumental – ultrasound, CT, PET/CT.

Results

The peculiarity of this case is that the disease started with persistently recurrent prolactinoma, which was characterised by the resistance not only to therapeutic but also to surgical treatment. Treatment with radiolabeled somatostatin analogues is a new promising treatment for patients with inoperable or metastatic neuroendocrine tumors.

Conclusions

The difficulty of diagnosis of patients with combined pathology is that by fixing on one disease, you can miss the beginning of the other diseases. In this particular case, by concentrating on a tumor of the pancreas, it was possible to omit the recurrence of prolactinoma.