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Endocrine Abstracts (2021) 73 PEP12.4 | DOI: 10.1530/endoabs.73.PEP12.4

1Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Endocrinology, Barcelona, Spain; 2Vall d’Hebron Research Institute (VHIR), Autonomous University of Barcelona (UAB), Diabetes and Metabolism, Barcelona, Spain


Sex hormone-binding globulin levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production. The main objective of this study was to assess if the adult associations between TNFα, Adiponectin and SHBG are present in prepubertal children. We determined several morphometric and biochemical parameters in normal-weight and obese prepubertal children, as well as quantified plasma SHBG, TNFα-R1, and adiponectin levels. Our results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/l vs 172 nmol/l). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNFα (negatively, ßstd = -0.31) and adiponectin (positively, ßstd = 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children. Furthermore, the results showed that plasma adiponectin levels are may play a more important role than TNFα in influencing plasma SHBG levels in our prepubertal population with obesity.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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