Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 75 | EYES2021 | Next issue

ESE Young Endocrinologists and Scientists (EYES) Annual Meeting

ea0075r01 | Reproductive Endocrinology | EYES2021

Androstenedione - the missing link: A case of 17β-hydroxysteroid dehydrogenase 3 deficiency

Sourabh Sagar , P R Manjunath , Kumbar Lohit , Naushad Altaf Ali

Introduction: 46 XY Disorders of Sex Development (46, XY DSD) is defined by the presence of female or incompletely virilized external genitalia in a 46, XY individual. 17β-hydroxysteroid dehydrogenase 3 (17βHSD3) deficiency is one of the causes for testosterone biosynthetic defects. It leads to defective conversion of androstenedione to testosterone. 17βHSD3 deficiency can present with female phenotype with inguinal hernias at birth, clitoromegaly during infancy...

ea0075r02 | Reproductive Endocrinology | EYES2021

How much do newly graduated healthcare professionals know about PCOS?

Jayaprakash Sindoora , Wicks Saskia , Sheikh Jameela , Zia Nawal , Hebbar Meghnaa , Narendran Alisha , Khalil Halimah , Melson Eka , Gillett Caroline D.T. , Kempegowda Punith

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine conditions affecting women of reproductive age. Recent studies have shown several long term comorbidities associated with PCOS, thus making it essential that all physicians, regardless of training and specialty, understand and empower women with PCOS to adopt evidence-based behavioral changes. This study set out to establish an understanding of evidence-based lifestyle management of PCOS and the current pract...

ea0075r03 | Reproductive Endocrinology | EYES2021

PCOS SEVa: High prevalence of anxiety, depression and body dysmorphia in people with PCOS suggesting we need to rethink how we screen and manage emotional wellbeing in people with PCOS

Hebbar Meghnaa , Zia Nawal , Sheikh Jameela , Wicks Saskia , Jayaprakash Sindoora , Narendran Alisha , Khalil Halimah , Melson Eka , Busby Maureen , Tahrani Abd A. , Hillman Sarah , Chapman Rachel , Gleeson Helena , Singh Ruchira , Robinson Lynne , Manolopoulos Konstantinos N. , Gillett Caroline D.T. , Thangaratinam Shakila , Arlt Wiebke , Kempegowda Punith

Aim: We evaluated the emotional wellbeing and lifestyle advice received by people with PCOS in comparison to National Institute of Health and Care Excellence (NICE) and international guidelines. Methods: Patients attending fertility clinics at Queen Elizabeth Hospital Birmingham between October 2020-May 2021 and in India between March 2021-May 2021 were invited to complete surveys before and after attending clinic. Pre-clinic survey had questions on demographics, Hospital Anxi...

ea0075r04 | Reproductive Endocrinology | EYES2021

Serum prolactin levels interact with menstrual fluctuations of arterial stiffness

Armeni Eleni , Delialis Dimitrios , Georgiopoulos Georgios , Augoulea Areti , Stergiotis Stefanos , Kontou Loraina , Chatzivasileiou Panagiota , Rizos Demetrios , Kaparos George , Baka Stavroula , Paschou Stavroula A , Mavraganis Georgios , Patras Raphael , Panoulis Konstantinos , Stamatelopoulos Kimon , Lambrinoudaki Irene

Objective: Prolactin has been adversely associated with arterial function in postmenopausal women but its vascular effects in reproductive women are unknown. Furthermore, although both circulating prolactin levels and markers of vascular function follow menstrual cycle (MC) phases, their possible inter-correlation has not been explored.Methods: Sixty healthy premenopausal women were evaluated in two distinct phases of their MC (follicular, F and luteal p...

ea0075r05 | Reproductive Endocrinology | EYES2021

Levels of circulating amyloid beta 1-40 are associated with the rate of progression of atherosclerosis in menopause

Armeni Eleni , Paschou Stavroula , Delialis Dimitrios , Georgiopoulos Georgios , Chatzivasileiou Panagiota , Karagkouni Iliana , Tual-Chalot Simon , Vlachogiannis Nikolaos I , Patras Raphael , Aivalioti Evmorfia , Augoulea Areti , Tsoltos Nikolaos , Soureti Anastasia , Stellos Konstantinos , Stamatelopoulos Kimon , Lambrinoudaki Irene

Background: Recent data is indicating that levels of circulating amyloid β 1-40 (αβ1-40), a proatherogenic aging peptide, may be considered as a novel biomarker in cardiovascular disease (CVD). Postmenopausal women represent a population with substantial unrecognized CVD-risk, which would benefit from identification of novel cardiovascular risk markers.Aim: To explore the role of plasma Aβ1-40 and its patterns of change over time in a...

ea0075r06 | Reproductive Endocrinology | EYES2021

Low testosterone is a predictor of hypoxemic respiratory insufficiency and higher mortality rate in SARS-CoV-2 hospitalized patients: A cohort study

Vena Walter , Pizzocaro Alessandro , Maida Giulia , Amer Myriam , Voza Antonio , Di Pasquale Andrea , Reggiani Francesco , Ciccarelli Michele , Fedeli Carlo , Lavezzi Elisabetta , Mazziotti Gherardo , Lania Andrea

Objective: To evaluate the association between testosterone (T) values and clinical outcome of COVID-19.Methods: This is a retrospective single-center study performed on 221 male patients (median age 70.5 years, range 26-93) with COVID-19 and hospitalized in our Institution between November 1st 2020 and January 31st 2021. Patients’ height, weight, BMI, medical history and comorbidities were recorded; at admission, patients underwent sampling for com...

ea0075r07 | Reproductive Endocrinology | EYES2021

Testicular microvascular flow is altered in Klinefelter syndrome and predicts circulating testosterone: a preliminary cross-sectional study

Carlomagno Francesco , Pozza Carlotta , Tenuta Marta , Pofi Riccardo , Tarani Luigi , Mazzotta Paola , Sesti Franz , Minnetti Marianna , Gianfrilli Daniele , Isidori Andrea M.

Background: Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS.Objective: To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular par...

ea0075r08 | Reproductive Endocrinology | EYES2021

Unveiling the therapeutic role of somatostatin and cortistatin in prostate cancer

Perez-Gomez Jesus M. , Saez-Martinez Prudencio , Jimenez-Vacas Juan M. , Herrero-Aguayo Vicente , Pedraza-Arevalo Sergio , Gomez-Gomez Enrique , Leon-Gonzalez Antonio J. , Castano Justo P. , Martinez-Fuentes Antonio J. , Gahete Manuel D. , Luque Raul M.

Background: Somatostatin (SST)/Cortistatin (CORT) system is a complex hormonal axis involved in the progression of several tumor types. However, its role has not been explored in prostate cancer (PCa), one of the most common type among men.Objectives: We aimed to investigate the presence and the pathophysiological role of SST/CORT in PCa.Methods: We analysed functional parameters in response to SST and CORT and to CORT-silencing in...

ea0075r09 | Reproductive Endocrinology | EYES2021

Evaluation of the urinary iodine concentration (UIC) in pregnant women using ion-pair HPLC-UV method

Mikulska Aniceta , Filipowicz Dorota , Głowka Franciszek , Szczepanek-Parulska Ewelina , Ruchała Marek , Karaźniewicz-Łada Marta

Background: Pregnancy is a state of a higher iodine intake demand. Proper iodine status is important during pregnancy for fetal neurodevelopment and maternal thyroid function. Urinary iodine concentration (UIC) is the most common indicator of iodine status.Objectives: The aim of this study was to develop and validate a novel ion-pair HPLC-UV method to measure iodine in urine and to assess iodine status in pregnant women.Methods: Sa...

ea0075r10 | Reproductive Endocrinology | EYES2021

Primary Amenorrhea – a case with Swyer Syndrome

Aksiks Jekabs , Erta Gita

Swyer syndrome (46XY karyotype) is a rare disorder of sexual development. Patients phenotypically appear female with normal external genitalia and vagina. 14 year old girl is evaluated for primary amenorrhea. She is 176 cm and weighs 61 kg (BMI=19.7 kg/m2) – she has had significant growth for the past year. The girl has a vagina with 7 cm in length, there is no terminal hair or breast development (Tanner I). MRI of pelvis shows uterine hypoplasia, ovary agenesi...

ea0075r11 | Reproductive Endocrinology | EYES2021

Assessing anxiety, depression and body dysmorphia in young women with and without PCOS: the Blue Morpho Gen Y Survey

Khalil Halimah , Sheikh Jameela , Hebbar Meghnaa , Zia Nawal , Wicks Saskia , Jayaprakash Sindoora , Narendran Alisha , Melson Eka , Busby Maureen , Tahrani Abd A. , Hillman Sarah , Chapman Rachel , Gleeson Helena , Singh Ruchira , Robinson Lynne , Manolopoulo Konstantinos N. , Gillett Caroline D.T. , Thangaratinam Shakila , Arlt Wiebke , Kempegowda Punith

Background: The National Institute of Health and Care Excellence (NICE) recommends evaluating emotional wellbeing in people with polycystic ovary syndrome (PCOS).Objectives: To study differences in various aspects of emotional wellbeing among young women with and without PCOS.Methods: Women aged 18-24 years old at the University of Birmingham were invited to complete an online survey. The survey included validated questionnaires in...

ea0075r12 | Reproductive Endocrinology | EYES2021

A difficult case of Burned-out testicular tumours: can orchiectomy be avoided?

Bonaventura Ilaria , Tenuta Marta , Mazzotta Paola , Minnetti Marianna , Gelibter Alain , Pozza & Andrea M. Isidori Carlotta

Background: Burned-out tumours (BOT) are rare clinical entities which present with no primary testicular lesion but distant metastases. We report a difficult management of BOT.Case Presentation: A 22-year-old male presented to ER with acute low back pain, severe vomiting and sweating. In past medical history: bilateral orchidopexy for cryptorchidism. Abdominal CT scan displayed two retroperitoneal masses of 35 and 20 mm. The patient was discharged with s...

ea0075r13 | Reproductive Endocrinology | EYES2021

Severe hyponatremia in a case of ovarian hyperstimulationSyndrome

Awala Orighomisan , Thadani Puja , Yesear Zhainab , Al-Rawe May , Ghobara Tarek , Sankar Sailesh , Rao Ranganatha , Randeeva Harpal , Murthy Narasimha

Background: Ovarian Hyperstimulation Syndrome(OHSS) complicates up to a third of assisted reproduction cycles. Severe hyponatremia is a rare complication of OHSS. We report a case of severe hyponatremia to highlight the challenges in management.Case Report: 31 year-old female presented with breathlessness, abdominal pain, increased abdominal girth and hyponatremia (sodium 122 mmol/l) eight days following embryo transfer after ovulation induction with gon...