Endocrine Abstracts

Background: COVID-19 is the pandemic of the new millennium. COVID-19 patients with comorbidities including hypothyroidism could develop a life-threatening situation. We would like to introduce the clinical manifestations of hypothyroidism that can aggravate COVID-19.Case Presentation: A 78-yo woman was admitted to Heratsi University hospital with general weakness and shortness of breath. She had a history of Hypertension and Paroxysmal atrial tachycardia...

Introduction: Hashimoto thyroiditis is the prominent face in thyroid diseases, and it is considered as an autoimmune disorder, in which the immune system develops antibodies against thyroid peroxidase enzyme which has a role in thyroid hormone production. No treatment for hashimoto thyroiditis itself, only patients with low thyroid hormone with high TSH levels require treatment with thyroxin. It is known that about 25 genes converting data regarding selenoproteins are present ...

Background: Hashimoto thyroiditis is the most common autoimmune disease, with a marked prevalence in women. Occasionally, it may be associated with renal disease. Most described renal lesion in patients with autoimmune thyroiditis is membranous glomerulonephritis.Case: A 32 years old Caucasian man consulted the endocrinologist with a 4 months history of progressive fatigue, headache, arthralgia, dryness of skin and increased weight of approximately 10 kg...

Background: Overt hyperthyroidism can have a negative impact on pregnancy’s outcome, if not correctly treated. Furthermore anti thyroid treatment are burned by possible side effects.Objectives: We describe the experience of our center in the management of endogenous hyperthyroidism in pregnancy. evaluating the effects of the disease and treatments on fetal and maternal health.Methods: We observed 36 pregnancies (4 twins and 1 ...

Backgroud: Distant metastases from papillary thyroid cancer (PTC) are infrequent and associated with poor prognosis. Adrenal metastatic lesions in this setting are rare, generally associated with lung and skeletal metastases. There have been few reported cases of isolated adrenal metastases from thyroid carcinoma. Here we report a patient with a PTC who developed a large and solitary adrenal metastasis.Case Presentation: A 68-year-old men was submitted i...

Background: Cushing’s syndrome (CS) in medullary thyroid cancer (MTC) is rare with less than 60 cases reported. Less than 1% of MTC develop ectopic ACTH-dependent CS and this correlated with metastasis at diagnosis and poor prognosis.Case presentation: A 32-year-old male was referred to our department for suspected CS. Initial evaluation showed hypokalemia(2.4 mmol/l) and severe ACTH-dependent CS (Cortisol h8:678ng/ml; ACTH:249pg/ml; urinary free co...

Introduction: Graves’ disease is associated with mild hypercalcemia in about 1/5th of cases. T3, through its nuclear receptor activates osteoclasts resulting in accelerated bone turnover. Although mild hypercalcemia is common in Graves’ disease, symptomatic hypercalcemia is rare. We describe a case who presented with thyrotoxic storm and hypercalcemia.Case report: 52-year-old lady presented with thyrotoxic symptoms of weight loss, dysphagia for...

Background: Endogenous and exogenous factors may cause biochemical interferences with thyroid function immunoassays. Interference can be caused by many mechanisms including heterophilic antibodies, drugs and rheumatoid factors. Moreover, assay-specific interference has been described, such as antithyroid hormone antibodies resulting in falsely elevated or lowered concentrations depending on the assay.Case Presentation: We describe a case of a 38-years ol...

Background: Myasthenia gravis and thyroid disease can sometimes create diagnostic confusion because the two may have similar clinical features and may also co-exist in the same individual.Case: A 68 years male, was seen in the Neurology clinic with drooping of his left eyelid, first noticed 8 months prior, worse in the evenings. There were no other complaints. He had history of type2 diabetes, and Graves’ disease. On examination, he appeared to have...

Background: Tyrosine Kinase Inhibitors show great promise in the management of metastatic Medullary Thyroid Carcinoma.Somatic mutations are considered to play a major role in the response/resistance to therapies.RET-somatic mutations are present in 45-75% of sporadic MTCs while RAS are rarer.Objectives: The aim of this study is to investigate the mutational profile of 18 spMTC pts, with metastatic/biochemical persistent disease and to look into possible ...

Background: Lenvatinib is an oral chemotherapy for metastatic radioiodine-refractory differentiated thyroid cancer (RRDTC) which significantly improves progression free survival (PFS). It has been proved that higher rates of dose interruption or reduction of Lenvatinib have a negative impact on PFS. Patients with active cancer, such as RRDTC, have an increased risk of contracting Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and developing complications, especial...

Background: Agranulocytosis is rare and may develop in 0.2–0.5% patients using antithyroid drug therapy (ATD). We report on a patient who developed febrile neutropenia two weeks after starting treatment with methimazole.Case Report: A 74-year-old female, with no relevant medical history, was diagnosed with Graves disease and treated with methimazole (30 mg/day). Three weeks after starting therapy she presented to the emergency department with compla...