Metabolic Bone
Nikoletta Mili 1 , Makarios Eleftheriades 2 , Stavroula Paschou 2 , Nikolaos Syggelos 2 , Areti Augoulea 2 , Eleni Armeni 2 , George Kaparos 3 , Anastasia Palaiologou 4 , Konstantinos Panoulis 4 , Homeira Vafai 5 , Ismene Dontas 6 , Katerina Marinou 7 , George Vaggos 8 , Panagiota Raptou 9 , Nikolaos Vlahos 2 , Irene Lambrinoudaki* 2 & Kypros H Nicolaides* 9
12nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens; [email protected]; 2Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece and Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital, London, UK; 3Biochemical Laboratory, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece; 4Department of Obstetrics and Gynecology, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; 5Laboratory for Research of the Musculoskeletal System, Th. Garofalidis, National and Kapodistrian University of Athens, KAT Hospital, Kifissia, Attica, Greece; 6Greek Ministry of Rural Development and Food, Department of Animal Welfare for Farm and Laboratory Animals, Athens, Greece; 7Department of Obstetrics and Gynecology, General Hospital of Arta, Arta, Greece; 8Laboratory for Research of the Musculoskeletal System, Th. Garofalidis, National and Kapodistrian University of Athens, KAT Hospital, Kifissia, Attica, Greece; 9Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital, London, UK
Objectives: This study aimed to assess the results of different perinatal nutritional patterns on skeletal development and insulin regulation of one-year-old Wistar rats.
Methods: Three different diet regiments [Control Diet, (CD), food-restricted (FR), or fat-fed (FF)] were randomly provided to sixty-seven primigravid rats from the 12th till the 21st gestational date when they gave birth and throughout the 25-day lactation period. According to their birth weight, offspring of FR-mothers were classified as fetal growth restricted (FGR) and non-FGR. After delivery, all pups were lactated by foster mothers receiving either the same or a different diet regiment than the birth mother. Weaning to the foster mother diet scheme occurred 26 days postpartum and that regiment was followed throughout the first year of life. One-year-old offspring’s skeletal characteristics were assessed using peripheral quantitative computed tomography and plasma insulin levels were measured.
Results: Total bone density and total/subcortical area were lower in FF/FF vs. CD/CD rats. From the group born to FF-mothers, those who were subsequently fat-fed (FF/FF) presented higher subcortical density in comparison to those who were subsequently food-restricted (FF/FR). Values of all measured skeletal characteristics were lower in FGR/CD vs CD/CD rats. Within the non-FGR group, postnatal high-fat diet was associated with higher values in all skeletal properties compared to food restriction. Insulin levels were higher in FGR/FF than in FF/FR rats. Postnatally FF rats had similar insulin levels, regardless of being born to an FR or FF mother.
Conclusions: Skeletal development and insulin production is associated with pre- and postnatal nutritional patterns.
Volume 75
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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