Endocrine Abstracts

Objectives: To report outcomes comparing RYGB (Roux-en-Y gastric bypass) and OAGB (one anastomosis gastric bypass) on patients with obesity. To further investigate the efficacy of OAGB, given that there is significant interest in OAGB as it has reported reduced operating time, better weight loss and increased remission of obesity-related comorbidities. However, there are concerns over potentially serious postoperative complications causing limited uptake.

Methods: We searched OVID Medline, EMBASE and the Cochrane Library databases from inception to November 23, 2020 for studies comparing OAGB and RYGB. The primary outcomes extracted were excess weight loss, remission rate of comorbidities and postoperative complications/adverse effects. For risk of bias assessment, ROBINS-I (Risk Of Bias In Non-randomized Studies of Interventions) and Cochrane Collaboration’s tool were used for cohort study and randomized controlled trials (RCTs) respectively. The current review has been submitted to PROSPERO (ID: CRD42021233284).

Results: We identified 4 RCTs and 34 cohort studies for meta-analysis, with a total number of 126,248 patients. The risk of bias was low for 8 cohort studies and 3 RCTs, moderate for 13 cohort studies, and serious for 13 cohort studies and 1 RCT.

Conclusions: As part of this ongoing systematic review and meta-analysis, we have identified a large number of studies to answer our clinical question and better inform patient care.