Reproductive Endocrinology
Eleni Armeni 1 , Stavroula Paschou 2 , Dimitrios Delialis 3 , Georgios Georgiopoulos 3 , Panagiota Chatzivasileiou 2 , Iliana Karagkouni 2 , Simon Tual-Chalot 4 , Nikolaos I Vlachogiannis 4 , Raphael Patras 3 , Evmorfia Aivalioti 3 , Areti Augoulea 2 , Nikolaos Tsoltos 2 , Anastasia Soureti 2 , Konstantinos Stellos 3 , Kimon Stamatelopoulos 5 & Irene Lambrinoudaki 2
1Menopause Clinic, 2nd Department for Obstetrics of Gynecology, National and Kapodistrian University of Athens; [email protected]; 22nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece; 3Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece; 4Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medicinal Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; 5Department of Cardiology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom
Background: Recent data is indicating that levels of circulating amyloid β 1-40 (αβ1-40), a proatherogenic aging peptide, may be considered as a novel biomarker in cardiovascular disease (CVD). Postmenopausal women represent a population with substantial unrecognized CVD-risk, which would benefit from identification of novel cardiovascular risk markers.
Aim: To explore the role of plasma Aβ1-40 and its patterns of change over time in atherosclerosis progression in postmenopausal women.
Methods: This is a prospective study, which recruited a tota of 152 postmenopausal women without any history of CVD or related symptoms. Aβ1-40 was measured in plasma by enzyme-linked immunosorbent assay. The extent of atherosclerosis was assessed using carotid high-resolution ultrasonography at baseline and after a median follow-up of 28.2 months.
Results: At baseline, we observed that higher values of Aβ1-40 were independently associated with higher measures of carotid bulb intima-media thickness (cbIMT) and the sum of maximal wall thickness in all carotid sites (sumWT) (p<0.05). Aβ1-40 levels were found to increase over time and were associated with decreasing renal function (p<0.05 for both). Accelerated progression of cbIMT, maximum carotid wall thickness and sumWT was evident in women with a pattern of increasing or persistently high Aβ1-40 levels (p<0.05 for all) after adjustment for baseline Aβ1-40 levels, traditional risk factors, and renal function.
Conclusion: In postmenopausal women, the rate of progression of subclinical atherosclerosis is associated with a pattern of increasing or persistently high Aβ1-40, irrespective of its baseline levels. These findings provide novel insights into a link between Aβ1-40 and atherosclerosis progression in menopause. Further research is required to clarify the clinical value of monitoring its circulating levels as an atherosclerosis biomarker in women without clinically overt CVD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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