Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2021

Edinburgh, United Kingdom
08 Nov 2021 - 10 Nov 2021

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Join us in Edinburgh for the flagship event of the Society for Endocrinology

Oral Poster Presentations

Metabolism, Obesity and Diabetes

ea0077op4.1 | Metabolism, Obesity and Diabetes | SFEBES2021

Investigating the role of the gut metabolome in appetite and obesity

Stephens Hannah , Ramgulam Anya , Franco-Becker Georgia , Tashkova Martina , Serrano Contreras Jose Ivan , Blunt Dominic , Garcia-Perez Isabel , Frost Gary , Murphy Kevin

Overweight and obesity is an escalating global health problem, affecting 40% of the population and being the 5th largest cause of death worldwide. Treatment options are limited, with pharmaceutical approaches being inadequate and the success of bariatric surgery being limited by its invasive nature. The regulation of appetite by small bioactive compounds in the gastrointestinal tract is an important target in antiobesity research. Metabolites from diet and both host and microb...

ea0077op4.2 | Metabolism, Obesity and Diabetes | SFEBES2021

3 mg Liraglutide ameliorates inflammation and improves hypothalamic regulation of energy homeostasis by modulation of Sphingosine-1-Phosphate signalling in super-responders

Spencer Lewis , Dimitriadis Georgios K , Duggirala Aparna , Bate Danielle , Davasgaium Allan , Al-Hasani Wiaam , D Miras Alexander , Le Roux Carel , Vincent Royce P , Randeva Harpal S , Tripathi Gyanendra

Background: Growing evidence suggests that hypothalamic lipid sensing plays a key role in controlling food intake, fat deposition and energy balance and that its dysregulation could lead to obesity and type 2 diabetes (T2D). Recent investigations reported that sphingosine-1-phosphate (S1P) is involved in the hypothalamic control of energy homeostasis. Intra-cerebroventricular administration of S1P decreased food intake and increased energy expenditure in rodents.<p class="...

ea0077op4.3 | Metabolism, Obesity and Diabetes | SFEBES2021

The Chemerin-CMKLR1 Axis is Functionally Important for Central Regulation of Energy Homeostasis

Dumbell Rebecca , Yun Haesung , Maclean Samantha L. , Pors Klaus , Helfer Gisela

Chemerin is a newly discovered chemoattractant adipokine and is a natural ligand for the G protein coupled receptor CMKLR1. Its role in the regulation of energy metabolism and inflammation makes it a promising candidate for urgently needed pharmacological treatment strategies for obesity. To demonstrate a central role of chemerin, we manipulated chemerin signalling in the arcuate nucleus, a specific hypothalamic region associated with appetite regulation. We designed a short-h...

ea0077op4.4 | Metabolism, Obesity and Diabetes | SFEBES2021

Audit of Clinical Outcomes with Dexamethasone in Patients Hospitalised with COVID-19

Narendranathan Divani , Richards Molly , Cassin-Scott Rebecca , Chia Eng Pei , Distaso Walter , Tan Tricia , Izzy-Engbeaya Chioma , Salem Victoria

Background: Dexamethasone significantly improved outcomes in patients requiring supplementary oxygen and in ventilated patients with COVID-19 in the RECOVERY trial. Consequently, dexamethasone is now routinely used in these patients. However, dysglycaemia is commonly associated with steroid use and is an established risk factor for poorer outcomes in COVID-19. In this study, we aimed to elucidate the effect of dexamethasone use in patients hospitalised with COVID-19 in a real-...