Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2021

Edinburgh, United Kingdom
08 Nov 2021 - 10 Nov 2021

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Join us in Edinburgh for the flagship event of the Society for Endocrinology

Oral Poster Presentations

Reproductive and Neuroendocrinology

ea0077op3.1 | Reproductive and Neuroendocrinology | SFEBES2021

Discordant growth hormone and insulin like growth factor-1 values are associated with an increased mortality over concordant normal values in patients treated for acromegaly

Abeyaratne Dayakshi , Kaniuka-Jakubowska Sonia , Plummer Zoe , Archer Natasha , Lakmal Fonseka Chathuranga , Ayuk John , Peter James , McNally Richard , Michael Orme Stephen , Rees Aled , Pal Aparna , Wass John

Background: Growth hormone (GH) and Insulin like growth factor 1 (IGF-1) discordance in patients with acromegaly is a well-recognised phenomenon. It is unclear whether this is associated with increased mortality and morbidity compared to patients with concordant normal results.Methodology: A retrospective study was conducted on the United Kingdom Acromegaly Registry (UKAR). A comparison of mortality and morbidity was performed among four groups categoris...

ea0077op3.2 | Reproductive and Neuroendocrinology | SFEBES2021

An ex-vivo human placental model demonstrates that temporal fluctuations in maternal glucose in gestational diabetes alter placental transcriptome networks associated vascular development and angiogenesis

Byford Abigail , Walsh Katy , Scott Eleanor , Forbes Karen

Aims: Women with gestational diabetes (GDM) who deliver large-for-gestational age (LGA) infants have subtle (1-1.5mM) differences in temporal maternal glucose control detectable by continuous glucose monitoring (CGM), compared to women who deliver appropriate-for-gestational-age (AGA) infants. It is unclear how these subtle changes cause LGA, but LGA has been linked to placental dysfunction. We aimed to develop an ex-vivo human placental model to mimic subtle differences in te...

ea0077op3.3 | Reproductive and Neuroendocrinology | SFEBES2021

‘Suppression imaging’ – a novel PET technique for increasing confidence in the localisation of secretory pituitary microadenomas

MacFarlane James , Kourlouri Olympia , Gillett Daniel , Senanayake Russell , Santarius Thomas , Tysome James , Donnelly Neil , Mendichovszky Iosif , Cheow Heok , Mannion Richard , Bashari Waiel , Gurnell Mark

Background: In a sub-group of patients with newly diagnosed pituitary adenomas, conventional MRI will fail to confidently localise the tumour. The role of molecular imaging for these patients is increasingly being recognised, both in terms of confirming diagnosis and in guiding targeted therapy; 11C-Methionine PET co-registered with volumetric MRI (Met-PET/MRCR) can enhance decision making in this group of patients. However, in some cases distinguishing t...

ea0077op3.4 | Reproductive and Neuroendocrinology | SFEBES2021

Stem cell heterogeneity and regulation in the postnatal pituitary gland

Willis Thea L. , Yianni Val , Santambrogio Alice , Russell John P , Lodge Emily , Charalambous Marika , Andoniadou Cynthia L.

The anterior pituitary gland is a critical endocrine organ responsible for many important physiological processes including puberty, fertility, metabolism and the stress response. It is derived from, and maintained by, a population of SOX2+ progenitor/stem cells which become more quiescent with age until their direct contribution to tissue turnover becomes negligible. Previous research has demonstrated that the postnatal SOX2+ population exhibits heterogeneity in terms of mark...