Endocrine Abstracts

Background: Congenital Adrenal Hyperplasia (CAH) requires exogenous steroid replacement and can be monitored with 17-OH Progesterone and Androstenedione. We reviewed real world data to evaluate these markers in relation to hydrocortisone dose in patients treated in 21 centres throughout 14 countries.Method: Retrospective cohort study using pseudonymised data from patients with 21α-Hydroxylase Deficiency recorded in the International Congenital Adren...

Background: The cardiovascular and metabolic outcomes of patients with AI are poor, and may be related to the non-physiological cortisol profile achieved with hydrocortisone treatment. Objectives: To describe salivary adrenal biomarkers, glucose and 24 hour ambulatory blood pressure (ABP) profiles, carotid intima media thickness (CIMT) and flow mediated dilatation (FMD) in CYP with primary AI, to improve knowledge of the relationship between non-physiolo...

Background: Adrenocorticotrophic hormone (ACTH) measurements can help determine the cause of adrenal insufficiency (AI), but AI is diagnosed using peak cortisol levels following Synacthen stimulation, not ACTH levels. ACTH levels are high in primary and low in secondary and tertiary AI. Primary AI is rare in childhood. At Sheffield Children’s Hospital (SCH) ACTH is measured as part of screening for AI, paired with an early morning cortisol, and at baseline (0 minutes) as ...

Background: There is wide variation in the reported rate of acute adrenal insufficiency (AI) related adverse events (sick day episodes and adrenal crises) between centres.Objective: Evaluate the level of consensus on the criteria that should be considered ‘essential’ for defining and managing adverse events associated with acute AI in children.Methods: Active users of the International Congenital Adrenal Hyperplasia &...

Introduction: Childhood Adrenocortical tumours (ACTs) are rare neoplasms of the adrenal glands, accounting for 0.2% of all childhood cancers. Cases are mainly sporadic, but some mutations have been identified. ACTs are usually benign unilateral adenomas, but rare malignant carcinomas have poor prognosis. We present a case of adrenal insufficiency following a unilateral adrenalectomy for a functioning adrenocortical adenoma in a child.Case: A 15 month old...

Background: The glucagon stimulation test (GST) involves administering an injection of glucagon and monitoring respondent levels of cortisol, growth hormone and glucose in the blood. The levels recorded are compared to current standard recommendations in order to offer a suggestion into growth hormone or cortisol deficiency. Many children who underwent the GST to investigate growth hormone deficiency (GHD) or prior to transfer to adult endocrine clinic failed to reach the adeq...

Introduction: Growth is considered as an important concern in patients with congenital adrenal hyperplasia (CAH). It is a group of recessive autosomal disorder which may develop due to genes mutation. In childhood, congenital adrenal hyperplasia (CAH) is considered as the most common inherited adrenal disorder. CAH can negatively affect the synthesis pathway of cortisol which leads to decrease cortisol level and a rise in the production of adrenocorticotrophic hormone. A high ...