Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Oral Communications

Oral Communications 11: Thyroid 2

ea0081oc11.1 | Oral Communications 11: Thyroid 2 | ECE2022

Thr92Ala polymorphism of the type 2 deiodinase (DIO2) is associated with higher risk of iatrogenic thyrotoxicosis in thyroidectomized subjects treated with levothyroxine and liothyronine

Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Simoni Manuela , Rochira Vincenzo , Santi Daniele , Brigante Giulia

Introduction: Hypothyroidism treatment is classically based on levothyroxine (LT4). However, 10% of hypothyroid patients treated with LT4 complain of hypothyroidism symptoms, despite normal thyroid stimulating hormone (TSH) serum levels. This ”peripheral hypothyroidism” has been linked to decreased availability of free triiodothyronine (fT3), likely related to single nucleotide polymorphisms (SNP) in deiodinase genes (DIO), reducing enzymatic activity. Since...

ea0081oc11.2 | Oral Communications 11: Thyroid 2 | ECE2022

What you choose makes the difference: the first medical therapy for amiodarone-induced thyrotoxicosis has significant implications on cardiovascular events and hospitalizations

Cappellani Daniele , Cosentino Giada , Morganti Riccardo , Manetti Luca , Bartalena Luigi , Bogazzi Fausto

Context: Amiodarone is a widely used anti-arrhythmic medication, however associated with a 15-20% rate of thyroid adverse effects. Amiodarone-induced thyrotoxicosis (AIT) is a complex disease due to diagnostic difficulties and therapeutic challenges. AIT patients often receive initial therapy for thyrotoxicosis before admission to a referral center. Whether the first-line medical therapy (i.e. therapies for thyrotoxicosis at first diagnosis of AIT) may affect the outcome of AI...

ea0081oc11.3 | Oral Communications 11: Thyroid 2 | ECE2022

PD-1/PD-L1 inhibitors and immune-related thyroid toxicity according to pre-existing thyroid dysfunction and TPO antibody levels: a single centre experience

Gruosso Giovanni , Nervo Alice Anna , Basile Sara , Migliore Enrica , D'Angelo Valentina , Ferrari Matteo , Roux Anna , Piovesan Alessandro , Arvat Emanuela

Background: Immune checkpoint inhibitors (ICIs) have modified the outcome of several advanced malignancies. Thyroid dysfunctions (DYSTHYR) are the most common endocrine immune-related adverse events (IRAEs) during treatment with the programmed cell death protein-1 (PD-1) and its ligand (PD-L1) inhibitors. Data regarding predictive biomarkers enabling stratification of DYSTHYR risk are still limited.Patients and methods: We retrospectively analyzed patien...

ea0081oc11.4 | Oral Communications 11: Thyroid 2 | ECE2022

Association of thyroid function and TPO positivity with the risk of postpartum depression: a population-based cohort study and systematic review

Sileo Federica , Osinga Joris , Visser Edward , Derakhshan Arash , citterio valeria , Persani Luca , Korevaar Tim

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...

ea0081oc11.5 | Oral Communications 11: Thyroid 2 | ECE2022

Positive correlation of thyroid nodule cytology with molecular profiling – analysis of over 4000 nodules from multicenter study and systematic literature review

Tessler Idit , Shochat Isaac , Cohen Oded , Payne Richard J , Avior Galit

Objectives: Despite the increasing role of molecular profiling, the association between mutation expression and pre-operative cytology for thyroid nodules has not been established.Methods: We collected data on patients who underwent molecular profiling of thyroid nodules in Bethesda categories III to VI from two tertiary academic hospitals and via systematic literature review. We tested the associations between Bethesda categories and molecular mutation ...

ea0081oc11.6 | Oral Communications 11: Thyroid 2 | ECE2022

A new grading system for medullary thyroid cancer

Prete Alessandro , Gambale Carla , Torregrossa Liborio , Bottici Valeria , Cappagli Virginia , Basolo Fulvio , Elisei Rossella , Matrone Antonio

Introduction: medullary thyroid carcinoma (MTC) is a neuroendocrine thyroidal cancer. World Health Organization recognizes a grading system for almost all neuroendocrine tumors; however, a shared grading system for MTC is still lacking. We performed a clinical and pathological review of 257 MTCs to evaluate which histologic features have an impact on the disease specific survival and to propose a new grading system.Method: We retrospectively reviewed cli...