Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Oral Communications

Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3

ea0081oc10.1 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Single-cell molecular and functional mapping of POMC neurons in obesity: a multi-modal approach

Leon Stephane , Simon Vincent , Lee Thomas H , Clark Samantha , Dupuy Nathalie , Le Feuvre Yves , Fioramonti Xavier , Cota Daniela , Quarta Carmelo

The brain plays a crucial role in maintaining the body’s energy needs, a process involving the activity of a group of hypothalamic neurons that express the neuropeptidergic marker pro-opiomelanocortin (POMC). POMC neuronal dysfunction can cause obesity and its associated metabolic sequelae. However, this population of neurons is highly diverse at a molecular and functional level, and whether or not such heterogeneity is implicated in disease establishment or progression h...

ea0081oc10.2 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Success in implementing changes in macronutrients intake in a high-protein and high-unsaturated fatty acids dietary intervention: 36-months results of the NutriAct randomized controlled multi-center trial

Pletsch-Borba Laura , Wernicke Charlotte , Meyer Nina , Nguyen Thu , Pohrt Anne , Gerbracht Christiana , Pfeiffer Andreas , Spranger Joachim , Mai Knut

Background & Aims: NutriAct is a 36-month randomized controlled multi-center trial aiming to analyze the effects of a dietary pattern focusing on a high-protein and high-unsaturated fatty acids (UFA) intake on healthy aging. We aimed to explore changes in intake of macronutrients and determine factors associated with a successful modulation of dietary pattern after 36 months in elderly community dwelling participants.Methods: 502 participants were ra...

ea0081oc10.3 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Glucose-dependent insulin secretion is regulated by mitochondrial-associated cannabinoid receptor type 1 (mtCB1)

Allard Camille , Zizzari Philippe , Clark Samantha , Dupuy Nathalie , Bermudez-Silva Francisco-Javier , Delgado Concepcion Lillo , Bellocchio Luigi , Marsicano Giovanni , Quarta Carmelo , Cota Daniela

Type 2 diabetes is among the most prevalent chronic diseases worldwide. Further research is needed to identify new mechanisms that may help preserve the function of insulin-secreting pancreatic β-cells. The cannabinoid receptors type 1 (CB1) and their endogenous ligands, endocannabinoids, exert a key role in regulating of glucose homeostasis, β-cells function, and insulin secretion. Intriguingly, CB1 is not only located at the plasma membrane (pmCB1), but also at the...

ea0081oc10.4 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Variants in obesity-related genes in a population with early-onset obesity

Kleyn Patrick , Ichetovkin Ilia , Moeller Ida H

Introduction: Genetic testing can improve the diagnosis of rare genetic diseases of obesity and identify patients who may benefit from targeted therapeutic intervention. For example, patients with genetic defects in the melanocortin-4 (MC4R) pathway may present with severe early-onset obesity and hyperphagia. Historically, however, genetic testing in patients with obesity has been limited. The Uncovering Rare Obesity® diagnostic genetic testing program aims to enhance acc...

ea0081oc10.5 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Splicing dysregulation is associated with aggresive and metabolic-associated liver disease-derived hepatocellular carcinoma

Sanchez Natalia Herman , Lopez-Canovas Juan L , del Rio-Morenos Mercedes , Amado Victor , de la Mata Manuel , Rodriguez-Peralvarez Manuel , Luque Raul M , Gahete Manuel D

Metabolic-associated fatty liver disease (MAFLD) is a growing cause of hepatocellular carcinoma (HCC), but the molecular mechanisms associated with the pathological progression from MAFLD to HCC are still to be fully elucidated. The genomic and transcriptomic profile of HCC samples have been widely described; however, the proteomic landscape of MAFLD-derived HCC samples is mostly unknown. Here, we sought to perform the first quantitative proteomic analysis of HCC samples from ...

ea0081oc10.6 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Opposite actions of LEAP-2 and ghrelin in energy homeostasis

Masa Sabela Casado , De Oliveira Diz Tadeu , Miguens Marta Varela , Gonzalez Carlos Dieguez , Carro Sulay Tovar

Liver-expressed antimicrobial peptide 2 (LEAP-2) has been recently characterized as an endogenous GHSR1a antagonist. LEAP-2 is produced mainly in the liver, and it was described that an acute ghrelin administration blocks food intake, GH release and normalize glucose levels during chronic caloric restriction. For this reason, it could be considered as a key endocrine factor in the regulation of systemic energy metabolism. Nevertheless, the exact mechanism of action is still un...