Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Oral Communications

Oral Communications 9: Environmental Endocrinology

ea0081oc9.1 | Oral Communications 9: Environmental Endocrinology | ECE2022

Higher free thyroxine associated with pfas exposure in first trimester. The odense child cohort

Jensen Richard Christian , Glintborg Dorte , Timmermann Clara Amalie Gade , Nielsen Flemming , Boye Henriette , Bilenberg Niels , Madsen Jeppe Buur , Grandjean Philippe , Jensen Tina Kold , Andersen Marianne

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). However, previous studies investigating associations between exposure to PFAS and thyroid hormone stat...

ea0081oc9.2 | Oral Communications 9: Environmental Endocrinology | ECE2022

Effect of legacy and new generation PFAS on thyrocyte function

De Toni Luca , Di Nisio Andrea , Dall'Acqua Stefano , Sut Stefania , Rocca Maria Santa , Ferlin Alberto , Foresta Carlo

Perfluoroalkyl substances (PFASs) have been claimed as thyroid disrupting chemicals since the exposure to several PFASs was significantly associated with thyroid hormones derangements. Demographics such as sex, age, and disease status likely influence the associations between PFASs exposure and thyroid hormones since major hypothyroidism effects were observed among pregnant women and infants. This study aims to evaluate of the possible impact of legacy and new-generation PFAS ...

ea0081oc9.3 | Oral Communications 9: Environmental Endocrinology | ECE2022

Transcriptional profiling of developing male rat perineum and phallus following exposure to the anti-androgenic fungicide triticonazole

Draskau Monica Kam , Lindgren Schwartz Camilla , Evrard Bertrand , Lardenois Aurelie , Pask Andrew , Chalmel Frederic , Svingen Terje

Androgen signaling is essential for male reproductive development and masculinization during fetal life. Developmental exposure to endocrine disrupting chemicals, not least those that disrupt androgen action, can lead to reproductive disorders such as cryptorchidism, hypospadias, and poor fertility. In rodent toxicity studies, as well as human epidemiological studies, a general biomarker for compromised fetal androgen signaling is a shorter anogenital distance (AGD) in male of...

ea0081oc9.4 | Oral Communications 9: Environmental Endocrinology | ECE2022

Morphostructural characterization of the testis in a large cohort of men living in highly polluted areas of Campania Region in south Italy: a focus on cadmium exposure

Garifalos Francesco , De Angelis Cristina , Di Nunzio Aldo , Menafra Davide , Castoro Michele , Verde Nunzia , Galdiero Giacomo , Piscopo Mariangela , Pivonello Claudia , Auriemma Renata Simona , Chiodini Paolo , Trifuoggi Marco , Colao Annamaria , Pivonello Rosario

Campania Region has been facing waste management crisis since 1980, characterized by urban, toxic and industrial waste illegal disposal, burying and incineration. Cadmium (Cd) is consistently shown to affect male reproductive function by multiple mechanisms, mostly elucidated in experimental models. The aim of the current single-center, observational, cross-sectional cohort study was to evaluate the prevalence of testis morphostructural alterations in a large cohort of men liv...

ea0081oc9.5 | Oral Communications 9: Environmental Endocrinology | ECE2022

Decoding the role of environmental cadmium exposure in thyroid disorders

Buha Aleksandra , Javorac Dragana , Baralic Katarina , Mandic-Rajcevic Stefan , Maric Djurdjica , Antonijevic-Miljakovic Evica , Djukic-Cosis Danijela , Zarkovic Milos , Antonijevic Biljana , Bulat Zorica

As a ubiquitously present metal, cadmium (Cd) represents a matter of great concern, especially considering its potential thyroid disrupting capacity. The study evaluated the connection between this environmentally relevant metal exposure and thyroid hormone levels. The DecodExpo study enrolled 425 participants (207 males and 218 females) with various disorders (236 participants) and healthy controls (189 participants). Collected blood samples were digested, and Cd levels were ...

ea0081oc9.6 | Oral Communications 9: Environmental Endocrinology | ECE2022

Iodine nutrition among adolescent Faroese comply with recommendations – are we home-safe?

Johannesen Herborg Liggjasardottir , Andersen Stig , Nielsen Kari Rubek , Weihe Pal , Petersen Maria Skaalum , Veyhe Anna Sofia

Introduction: Iodine nutrition is critical for human health. In recent years the main focus was on the developing brain during pregnancy. In addition, iodine nutrition is essential for growth and development during adolescence. Iodine nutrition was recently low within the recommended range among adult Faroese living on local, iodine-rich marine food items. Dietary habits among young generations are drifting away from local foods, and this raises a concern that led us to perfor...