Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Rapid Communications

Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3

ea0081rc10.1 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Insulin resistance as indexed by the estimated glucose disposal rate and liver fat content are correlated in type 1 diabetes

Mertens Jonathan , Spinhoven Maarten , Dirinck Eveline , Vonghia Luisa , Francque Sven , De Block Christophe

Introduction: The prevalence of metabolic syndrome is increasing in individuals with T1D, which could potentiate the development of NAFLD. The pathophysiology of NAFLD in T1D is still unclear, due to the co-existence of predisposing and protective factors. Insulin resistance (IR) is theorized as a key driver of NAFLD.Aim: We investigated the association between liver fat content (LFC), NAFLD, and IR in individuals with T1D. Subjects underwent magnetic re...

ea0081rc10.2 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Weight changes and all-cause mortality in patients with prediabetes and diabetes

Li Jia , Simon Gyorgy , Castro M. Regina , Caraballo Pedro

Introduction: Weight loss is a cornerstone in the management of prediabetes and diabetes mellitus. The association between weight and all-cause mortality is controversial and even paradoxical. Studies usually assess baseline weight. Studies assessing weight changes over time are limited. We present preliminary results of our attempt to model weight changes in patients with prediabetes and diabetes assessing the relationship with all-cause mortality.Metho...

ea0081rc10.3 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Primary bile acids differentially regulate differentiation of human abdominal and gluteal pre-adipocytes

Sabaratnam Rugivan , da Conceicao Ismael , Loh Nellie , Christodoulides Constantinos , Karpe Fredrik , Tomlinson Jeremy , Nikolaou Nikolaos

Bile acids (BAs) are synthesised from cholesterol in the liver and promote lipid digestion. An emerging body of evidence, however, suggests that BAs are also key signaling molecules with potent metabolic and endocrine functions, exerting their effects through activation of BA receptors, including the farnesoid-X- (FXR) and the G-protein-coupled- (TGR5) receptors. Disturbed BA synthesis has been associated with type 2 diabetes mellitus and insulin resistance, and recent studies...

ea0081rc10.4 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Adequate metabolic control at early stages of childhood onset type 1 diabetes prevent diabetic neuropathy: a 30 year follow up study

Baldimtsi Evangelia , Amezcua Salvador , Olausson Hakan , Ludvigsson Johnny , Hyllienmark Lars , Wahlberg Jeanette

Background and aims: Diabetic neuropathy is a common complication of type 1 diabetes. In this study we investigated the importance of long-term metabolic control for the development of diabetic neuropathy in patients with type 1 diabetes diagnosed in childhood.Materials and methods: Longitudinal cohort study. Twenty-five patients (9 women 16 men) were studied three times with neurophysiological measurements and clinical examinations. At baseline the pati...

ea0081rc10.5 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

GLP-1RAs and glucagon can reshape adipose differentiation in vitro by activating the “browning process”

Cantini Giulia , Trabucco Martina , Fei Laura , Propato Arianna , Guasti Daniele , Quartararo Giovanni , Maggi Mario , Mannucci Edoardo , Luconi Michaela

Obesity is associated with increased and dysfunctional white adipose tissue (WAT). Pharmacological approaches of obesity are still far from obtaining a stable weight loss. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been proposed as anti-obesity drugs due to their effects on weight loss. Furthermore, dual agonists engaging both GLP-1 and glucagon are currently under investigation for their marked effects on weight loss, although their mechanisms of action is stil...

ea0081rc10.6 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Differences in prevalence of, and precipitating factors for, diabetes related ketoacidosis in type 1 and type 2 diabetes mellitus

Zhou Dengyi , Sheikh Haaziq , Rajendran Dineshwaran , Soghal Shamanth , Yip Wai Nga Alice , Anilkumar Anjitha , Hebbar Meghnaa , Rengarajan Lakshmi , Krishnasamy Senthil , Narendran Parth

Introduction: Diabetes related ketoacidosis (DKA) is usually associated with type 1 diabetes mellitus (T1DM). However, DKA is increasingly being recognised in type 2 diabetes mellitus (T2DM). We studied the differences in prevalence and precipitating factors of DKA between T1DM and T2DM.Methods: This retrospective study included all DKA episodes from January to November 2021 in six hospitals in the West Midlands, UK. DKA was diagnosed as serum glucose&#8...

ea0081rc10.7 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Knowledge about Diabetic Ketoacidosis in Patients with Type 1 Diabetes mellitus – Data of a Patient-centered Questionnaire

Hepprich Matthias , Stiebitz Sebastian , Schultes Bernd , Schmitz Daniela , Felix Barbara , Rutishauser Jonas , Schubert Sabine , Roser Pia , Aberle Jens , Rudofsky Gottfried

Background/Introduction: Diabetic ketoacidosis (DKA) is a severe complication of diabetes mellitus type 1 (T1DM) with potentially life-threatening course. Data on patient knowledge about DKA in German-speaking countries is rare. Thus, we aimed to gather data about T1DM patientsÂ’ knowledge in terms of DKA.Methods: Together with two T1DM patients and an experienced diabetes counselor, we developed an anonymous questionnaire covering general knowledge ...

ea0081rc10.8 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Long-term treatment with glucagon-like peptide-1 (GLP-1) receptor agonists: a real-life study

Piccini Sara , Favacchio Giuseppe , Mazziotti Gherardo , Lania Andrea , Mirani Marco

RCTs and real-life studies have shown the efficacy of GLP-1 RAs on weight loss, glycemic outcomes, and prevention of cardiovascular (CV) events, but long-term data are lacking. This was a retrospective cohort study of 253 patients with a first prescription of a GLP-1 RA between 2009 and 2016 and a minimum follow-up of 5 years. The endpoints of the study were weight and glycemic outcomes. Secondary endpoints were the occurrence of renal and CV events, comparing patients with GL...