Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

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The 24th European Congress of Endocrinology (ECE) and the Italian Society of Endocrinology look forward to welcoming you to Milan. ECE 2022 returns for a four day, six parallel session festival of endocrine science. You can join us In person in Milan, Italy OR Live @Home online!

Rapid Communications

Rapid Communications 8: Calcium and Bone

ea0081rc8.1 | Rapid Communications 8: Calcium and Bone | ECE2022

Growth hormone excess in fibrous dysplasia and mccune albright syndrome (FDMAS)

Dănilă Oana O , Geels Raya ES , Claessen Kim , Meier Maartje E , Winter Elizabeth M , Biermasz Nienke , Appelman-Dijkstra Natasha M

Introduction: Fibrous dysplasia (FD)/McCune Albright Syndrome (MAS) is a rare disorder affecting bone and hormonal glands. In FDMAS patients, autonomous GH hypersecretion (GH+) is the most common endocrinopathy after Precocious Puberty and has a great impact on the morbidity and complication rate in patients with craniofacial fibrous dysplasia. However clinical and biochemical features of GH over secretion can be subtle and awareness is warranted. We aimed to explore the GH/IG...

ea0081rc8.2 | Rapid Communications 8: Calcium and Bone | ECE2022

Temporal effects of encaleret (CLTX-305) on mineral physiology in autosomal dominant hypocalcemia type 1 (ADH1): results from a phase 2B, open-label, dose-ranging study [NCT04581629]

Gafni Rachel , Hartley Iris , Roszko Kelly , Pozo Karen , Nemeth Edward , Sani-Grosso Ramei , Mathew Arun , Sridhar Ananth , Scott Roberts Mary , Fox Jonathan , Collins Michael

Autosomal dominant hypocalcemia type 1 (ADH1), caused by gain-of-function variants in the calcium-sensing receptor (CaSR, gene: CASR) and is characterized by hypocalcemia, hyperphosphatemia, low parathyroid hormone (PTH), and hypercalciuria. Calcilytics (negative allosteric modulators of the CaSR) decrease the sensitivity of activated receptors to extracellular calcium and normalize blood and urine abnormalities in ADH1 rodent models. Encaleret is an oral calcilytic u...

ea0081rc8.3 | Rapid Communications 8: Calcium and Bone | ECE2022

What is the most efficient way to fortify food items with vitamin D? A randomised, multiple crossover study

Espersen Rasmus , Ring Madsen Lene , Nebel Caroline , Danielsen Marianne , Dalsgaard Trine , Rejnmark Lars

Introduction: Vitamin D insufficiency (25-hydroxy vitamin D <50 nmol/l) is a global health problem. Vitamin D food fortification might be the solution, but knowledge is sparse on whether fortification of various food items affects the bioavailability differently. It is generally assumed that ingesting vitamin D with a fatty meal improves the bioavailability of vitamin D. Furthermore, complex formation with whey protein isolate (WPI) may enhance the stability of vitamin D a...

ea0081rc8.4 | Rapid Communications 8: Calcium and Bone | ECE2022

Accuracy, costs and radiation exposure of current preoperative localization procedures in patients with primary hyperparathyroidism, a retrospective cohort study in a Swiss tertiary referral center

Siegenthaler Martin , Christopher Maas Ole , Renstrom Frida , Clerici Thomas , Forrer Flavio , Kolb Walter , Sinz Stefanie , Bilz Stefan

Background: Focused parathyroidectomy has become the standard procedure for patients with sporadic primary hyperparathyroidism (pHPT) fulfilling the criteria for surgical therapy and requires preoperative localization procedures. Ultrasound imaging (US) and 99mTc-sestamibi-scintigraphy with/without SPECT/CT (SC) are established first line procedures. 18F-choline PET/CT (PET) has emerged as a novel sensitive and specific method. However, current reimbursem...

ea0081rc8.5 | Rapid Communications 8: Calcium and Bone | ECE2022

Estradiol is the major sex steroid regulating bone marrow fat in both men and women: a study in transgender persons

Tebbens Marieke , Schutte Moya , Troelstra Marian , Nederveen Aart , den Heijer Martin , den Heijer Peter H

Background: Bone marrow fat is a unique fat depot that is regulated independently of other fat depots. Estradiol is an important regulator of bone marrow fat. This is illustrated by an increase in marrow fat fraction after menopause and a decrease following estradiol replacement. We hypothesize that estradiol is the major sex steroid that regulates bone marrow fat not only in women, but also in men.Methods: This is an open-label partly randomized interve...

ea0081rc8.6 | Rapid Communications 8: Calcium and Bone | ECE2022

Health related quality of life in adults with hypoparathyroidism in an exploratory analysis of the phase 2 PaTH forward trial of TransCon PTH

Palermo Andrea , Vokes Tamara J , Khan Aliya , Rubin Mishaela , Schwarz Peter , Clarke Bart L , Eriksen Erik , Marcocci Claudio , Pagotto Uberto , Tsourdi Elena , Sikjaer Tanja , Brod Meryl , Mcleod Lori , Markova Denka , Noori Wahidullah , Eng Walter Frank , Shu Aimee , Smith Alden

Background: Patients with hypoparathyroidism experience significant physical and cognitive symptoms and reduced health-related quality of life (HRQoL). Conventional therapy for hypoparathyroidism does not fully alleviate diminished HRQoL. The Hypoparathyroidism Patient Experience Scales (HPES) were developed to assess disease-specific physical and cognitive symptoms as well as the impact of hypoparathyroidsm on HRQol. TransCon PTH, an investigational long-acting prodrug of par...

ea0081rc8.7 | Rapid Communications 8: Calcium and Bone | ECE2022

The resorption status of magnesium screws for surgical treatment of ankle fractures assessed by HRpQCT – 2.5 years follow-up data of a first-in-human study

Foszl Ines , Labmayr Victor , Wittig Ulrike , Martina Weinberg Annelie , Holweg Patrick , Obermayer-Pietsch Barbara

Background: Bioresorbable screws for surgical fracture treatment are of great interest for the orthopaedic community. Such implants are designed to provide stability and compression of the fracture and should dissolve after healing, thereby making removal of surgical material obsolete. Magnesium implants are a new material option. So far, long-term follow-up of fracture healing and material decay has not been studied in human. Here, we present the results of the 2.5 year follo...