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Endocrine Abstracts (2022) 81 EP1036 | DOI: 10.1530/endoabs.81.EP1036

Fattouma Bourguiba Hospital, ENT, Monastir, Tunisia


Introduction: Anaplasic thyroid carcinoma is an extremely aggressive undifferentiated tumor of follicular cell origin. It is uncommon and comprising approximately 1% of all thyroid cancers.

Purpose of the presentation: The objective of this work is to determine the clinical, histological and therapeutic aspects of anaplasic thyroid carcinoma.

Methods: This is a retrospective study about 4 patients treated for an anaplasic thyroid carcinoma, in the ENT department of Fattouma Bourguiba hospital in Monastir over a period of 22 years (2000-2021).

Results: The average age was 68 years. A female predominance was noted. The average consultation time was 2 months. Patients consulted for a rapidly progressive goitre in all cases, associated with dysphagia and dyspnea in 3 cases (75%). Cervical examination showed a painful and indurated anterior cervical swelling with a medium size of 5 cm in all patients. Associated lymph nodes were found in 2 cases (50%). Indirect laryngoscopy showed laryngeal paralysis in 2patients (50%), one of which was bilateral (25%). Cervical ultrasound and cervico-thoracic scan showed a mass pushing back the trachea in three cases (75%). 3 patients (75%) had an emergency tracheostomy with thyroid biopsy. The other patient underwent a lobo-isthmectomy. Radiotherapy was indicated in all cases. The evolution was fatal in all patients with a survival of less than 6months.

Conclusion: Anaplastic thyroid cancer is a very rare case and has a poor prognosis. The important information such as clinical manifestations, physical examination and imaging are necessary to diagnose and administer the proper management.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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