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Endocrine Abstracts (2022) 81 EP1045 | DOI: 10.1530/endoabs.81.EP1045

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1Saint Spiridon County Hospital, Endocrinology, Iaşi,; 2Saint Spiridon County Hospital, Surgery, Iaşi, Romania; 3‘Grigore T. Popa‘ University of Medicine and Pharmacy of Iaşi, Iaşi, Romania; 4Saint Spiridon County Hospital, Pathology, Iaşi, Romania


Introduction: Metastatic disease into the thyroid is a rare event, despite the gland’s rich vascular supply. Renal cell carcinoma (RCC) is an unusual neoplasm that not only has the potential to recur after a latent disease-free interval, but also has the potential to metastasize to rare sites like the thyroid. However, of the clinically significant secondary neoplasms of the thyroid, metastatic RCC is the culprit in most cases.

Case report: We present the case of a patient with metachronous RCC metastasis to the thyroid. A 62-year-old male with a 2-year history of non-toxic multinodular goiter was admitted to our Endocrinology Department. He had a history of multiple malignancies: 5 years earlier he had been diagnosed with clear cell RCC (ccRCC) (for which a left nephrectomy was performed) as well as basal cell carcinoma and 25 years earlier he had been diagnosed with colon cancer. Ultrasound evaluation documented a solid, very hypoechoic right thyroid nodule with significant growth, but fine needle aspiration biopsy couldn`t be performed because of the nodule’s posterior position. Considering the sonographic features of the lesion, the inability to perform a biopsy and the history of prior malignancies, we recommended surgical treatment. A total thyroidectomy was performed. Immunohistochemistry findings, along with the patient’s history, confirmed the diagnosis of thyroid metastasis from ccRCC. The patient was subsequently referred to an oncologist for further evaluation and treatment and he received targeted therapy with Sunitinib.

Conclusions: RCC recurrence after nephrectomy is highly variable, presenting with metastasis ranging from a few months to several years after the initial diagnosis. Metastatic RCC to the thyroid should be considered in any patient presenting with a thyroid mass and a medical history of RCC.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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