Endocrine Abstracts

Introduction: The association of thyroid and colon cancer is rare, it can be observed in the context of Gardner’s syndrome and Cowden’s syndrome with a prevalence of 0.6%. We report a case of metachronous association of a differentiated thyroid cancer with a colon cancer.

Observation: 45-year-old patient, followed for well-differentiated colonic adenocarcinoma without metastasis, having received eight courses of chemotherapy. One year later, the patient underwent a total thyroidectomy for multinodular goiter. Anatomopathologic examination of the surgical specimen showed a papillary carcinoma with vesicular differentiation classified as PT3. The patient received additional treatment with radioactive iodine131 at a dose of 100mci. The extension workup did not reveal any metastasis and the surveillance workup did not reveal any recurrence.

Conclusion: Multiple primary cancers are rare, but their incidence has recently increased. Common genetic and environmental risk factors seem to be involved in many cases. Multiplicity itself is not necessarily a poor prognostic factor. However, early detection will allow prompt management and increase the cure rate of the disease.