Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2022) 81 EP1149 | DOI: 10.1530/endoabs.81.EP1149

ECE2022 Eposter Presentations Thyroid (219 abstracts)

A female patient with diffuse sclerosing variant of papillary thyroid cancer and background autoimmune thyroiditis

Zoi Efstathiadou 1 , Athanasia Michou 1 , Efstathios Divaris 1 , Apostolos Gogakos 1 , Athanasios Panagiotou 1 , Prodromos Hytiroglou 2 & Marina Kita 1

1“Hippokration” General Hospital of Thessaloniki, Department of Endocrinology, Thessaloniki,; 2Aristotle University of Thessaloniki School of Medicine, Department of Pathology

Introduction: Diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) represents a rare but rather more aggressive subtype of PTC.

Purpose: Description of a patient with DSPC and background autoimmune thyroiditis.

Case description: A 33-year-old female patient reported extensive neck swelling that had progressed over several months. The patient had been diagnosed with hypothyroidism attributed to autoimmune thyroiditis, 3 years before. At that time, goiter was also found with a reported predominant nodule in the right lobe. On examination, the patient was euthyroid, with a palpable enlargement of the right lobe and isthmus, with particularly hard texture. Ultrasound imaging revealed diffuse enlargement of the thyroid gland particularly of the right lobe, where a formation of a suspicious mass was noted. Linear hyperechogenic foci were dispersed throughout the entire thyroid surface. Hypoechogenic areas with ill-defined borders were noted centrally, possibly representing lymph nodes. A fine-needle aspiration biopsy of the right lobe was positive for papillary thyroid cancer and the patient underwent total thyroidectomy. Histopathology showed a 2.4 cm papillary carcinoma of the right lobe, with psammomatus bodies, squamous metaplasia, and background sclerosis. Vascular infiltration by the tumor cells was present. The remaining thyroid parenchyma exhibited extensive lymphocytic and plasmatocytic infiltrates with abundant lymphoblastic centers. Dispersed foci of the neoplasm were observed in all sections of the entire gland. Metastases were recognized in 3 excised central lymph nodes. A few weeks later the patient underwent a completion surgery with central and right lateral compartment exploration, with metastases found in 13/24 and 4/30 lymph nodes, respectively.

Conclusions: The imaging characteristics and the overlapping presence of Hashimoto’s thyroiditis can lead to a delayed diagnosis of DSPC. Considering the more aggressive nature of this variant, raising awareness for early recognition of its particular ultrasonographic characteristics is of paramount importance for effective treatment and improved prognosis.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.