Endocrine Abstracts

Background: Previous studies show that lead levels are closely related with obesity, and severe weight reduction in obese women increases skeletal bone mobilization and blood lead levels especially postmenopausal women. However, it is under the curtain if blood lead level is associated with menopause, weight recycling in women until now.

Methods: We assessed weight, height, waist circumferences and obtained past medical histories, blood lead levels as well as socio-demographic, cardio-metabolic variables of 1043 women participated KNHANES (Korea National Health Analysis Nutrition Examination Survey) in 2018. All participants were recategorized into four groups [premenopausal weight loss (-1), premenopausal weight stable (0), postmenopausal weight stable (1), postmenopausal weight gain (2)]. ANCOVA tests were performed using by SPSS for window (Ver. 18, Il, USA) and probabilities less than 0.05 was significant at both sided.

Results: Higher blood lead levels showed significantly associated with higher cardio-metabolic risk variables (hypertension, hyperglycosemia, hypertriglyceridemia, and low HDL cholesterolemia), more obese in postmenopausal weight recycling gain group. (P<0.01)

Discussion and Conclusion: Further controlled clinical trial would be considered in the future. We concluded that higher blood lead levels were associated with postmenopausal Korean women with weight recycling. Keyword: blood lead level, obesity, menopause, weight recycling, women