Endocrine Abstracts

The role played by physical activity in promoting bone health is now widely recognized. Physical activity limits and slows down the physiological demineralization that occurs over the years and plays an important role in the prevention of osteoporosis. SuperJump, a high-impact training activity performed on a mini-trampoline characterized by alternating between aerobic and anaerobic exercises, has been shown to be able to generate a substantial osteogenic response and increase bone balance and strength in eumenorrheic women. In this study it was analyzed whether gastrointestinal peptides play a role in the regulation of bone metabolism and their impact on glucose homeostasis. Methods Using a randomized controlled study design, participants were assigned either to the intervention group performing SuperJump activity for 20 weeks or to the control group, that did not undertake any intervention. Blood samples were collected at baseline and at the end of the study and compared within and between the groups for markers of bone metabolism (CTX, osteocalcin, PTH, Vitamin D, albumin adjusted calcium) gut peptides (GLP-1, GIP, GLP-2, PYY, ghrelin) markers of glucose metabolism (glucose, insulin, insulin resistance, β-cell function, insulin sensitivity). Results After 20 weeks of SuperJump activity, CTX and PTH was reduced, GLP-1 and GIP levels were significantly increased while levels of GLP-2, PYY and ghrelin did not change. Moreover, SuperJump activity significantly reduced fasting insulin, glucose, insulin resistance and increased insulin sensitivity but did not affect beta cell function.ConclusionThe results of the study show that 20 weeks of SuperJump was highly effective in improving bone and glucose homeostasis in eumenorrheic women and suggests that GLP-1, and GIP are involved in the mechanism of action.